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    A-PHENICOL D 0.1%+0.5% Ophthalmic Solution

    A-PHENICOL D 0.1%+0.5%

    Generic: Dexamethasone + Chloramphenicol

    Category: Ophthalmic Solution

    Manufacturer: ACME Laboratories Ltd.

    Price: 70.21 ৳

    5ml Drop

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    Indications

    Eye Drop is used for: Allergic conjunctivitis, Acute purulent conjunctivitis, Corneal ulceration, Keratitis disciformis, Post-herpetic keratitis, Allergic blepharitis, Acute and chronic iritis, Iridocyclitis, Otitis externa, infective and inflammatory ear infections.

    Dosage and Administration

    Adult: Instill 1 drop of asolution every 2 hr. Increase dosage interval upon improvement. To continue treatment for at least 48 hr after complete healing. Otic/Aural Otitis externa Adult: Instill 2-3 drops into the ear bid-tid.

    Contraindications

    History of hypersensitivity or toxic reaction to the drug; Perforated ear drum. Herpes simplex and other viral conditions of the eye or ear, mycosis.

    Side Effects

    Side effects of Chloramphenicol 0.5% + Dexamethasone 0.1% Eye/Ear drop : Ophthalmic application: Hypersensitivity reactions including rashes, fever and angioedema. Ear drops: Ototoxicity.

    Precautions And Warnings

    Avoid prolonged use. Discontinue immediately if local hypersensitivity reactions occur.

    Mode of Action

    Dexamethasone is a synthetic glucocorticoid which decreases inflammation by inhibiting the migration of leukocytes and reversal of increased capillary permeability. It suppresses normal immune response. Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase.
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