Uses of Wikijet 10 Injection: - Muscle relaxation Spasticity, Painful muscle spasm Severe hepatic dysfunction.

How to use Tizanidine: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tizanidine may be taken with or without food, but it is better to take it at a fixed time. Adult Dose: Oral Muscle Spasticity Spasticity associated with multiple sclerosis and spinal cord injury Initial: 2 mg q6-8hr; no more than 3 doses q24hr Maintenance: Increase by 2 to 4 mg until satisfactory response is achieved with minimum 1-4 days between dose increments Not to exceed 36 mg/day Painful muscle spasm associated with musculoskeletal conditions Adult: 2-4 mg tid. Elderly: Not recommended. Hepatic impairment: Avoid or use with extreme caution. Child Dose: Child < 18 years: Not recommended Renal Dose: Renal impairment: CrCl (ml/min) Dosage Recommendation <25 Initially, 2 mg once daily, gradually increasing the dose before increasing the frequency of admin.

Potentiates hypotensive effect of antihypertensives. Increased CNS effects with alcohol and CNS depressants. Increased bradycardia with ?-blockers and digoxin. Increased serum concentration of tizanidine with CYP1A2 inhibitors e.g. zileuton, ciprofloxacin and other fluoroquinolones, antiarrhythmics, cimetidine, famotidine, oral contraceptives, aciclovir and ticlopidine. Decreased serum concentrations of tizanidine with rifampicin. Use with caution with drugs that may prolong QT interval.

Severe hepatic dysfunction.

Common - Dizziness - Sleepiness - Dryness in mouth - Upset stomach >10% Dry mouth (46-50%),Somnolence (46-50%),Dizziness (16-20%),Asthenia (10-45%) 1-10% Blurred vision (3%),Constipation (4%),Infection (6%),LFT abnormalities (3-5%),Speech disorder (3%),Vomiting (3%),Urinary frequency (3%),UTI (10%) Frequency Not Defined Asthenia,Bradycardia,Hypotension,Orthostatic hypotension,Syncope (rare) Potentially Fatal: Hepatitis.

Precaution: Hepatic or renal insufficiency. Children, elderly, pregnancy and lactation. Monitor LFT regularly. Stop treatment if liver enzymes are raised persistently >3 times upper limit of normal range. Avoid abrupt withdrawal of therapy. Lactation: May be excreted in breast milk due to lipophilic nature; use caution

Tizanidine, an alpha2-adrenergic agonist, is a centrally acting muscle relaxant structurally related to clonidine. It reduces spasticity by increasing presynaptic inhibition of motor neurons and has no direct effect on skeletal muscle, the neuromuscular junction or on monosynaptic spinal reflexes.