Uses of Vitilen Lotion: - Vitiligo - Psoriasis Psoriasis, Vitiligo, Eczema, T-Cell Lymphoma Hypersensitivity. Aphakia, existing or history of melanoma, invasive squamous cell carcinoma, photosensitivity diseases (e.g. porphyria, acute lupus erythematosus, xeroderma pigmentosum).

Methoxsalen preparation

Methoxsalen increases skin reactivity to long-wavelength UV rays. It bonds covalently to deoxyribonucleic acid (DNA), thus inhibiting DNA synthesis and suppressing cell division and epidermal turnover. This effect is used in photochemotherapy or PUVA [psoralen (P) and high-intensity long-wavelength UVA irradiation].

How to use Methoxsalen: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Methoxsalen is to be taken with food. Administration: Apply over lesions then expose to UVA immediately after application or wait up to 2 hr. Protect the area surrounding the lesion w/ a sunscreen. Wash and protect lesions from light after treatment; protection may be up to >48 hr. Treatment is usually repeated once wkly. Substantial repigmentation usually requires 6-9 mth of treatment. Adult Dose: Topical Vitiligo: Adults and children 12 years of age and over Apply to the affected area of the skin 2 hr before UV exposure q3-7 days. The amount and time of UVA light for each treatment is based on skin type and response to treatment. patient may have UVA light treatments 2 to 4 times a week when first start and then less frequently as condition improves. Child Dose: Topical Vitiligo: Children 12 years of age and over Apply to the affected area of the skin 2 hr before UV exposure q3-7 days. <12 years old: safety and efficacy not established

Additive effects with drugs known to cause photosensitisation e.g. anthralin, coal tar or derivatives, griseofulvin, phenothiazines, nalidixic acid, sulfonamides., tetracyclines and thiazide diuretics. May increase the levels/effects of aminophylline, fluvoxamine, mexiletine, mirtazapine, ropinirole, theophylline, trifluoperazine, dexmedetomidine and ifosfamide.

Hypersensitivity. Aphakia, existing or history of melanoma, invasive squamous cell carcinoma, photosensitivity diseases (e.g. porphyria, acute lupus erythematosus, xeroderma pigmentosum).

Common - Itching All Patients Mild-moderate erythema x 24-48 hrs 1-10% Nausea,Pruritis Frequency Not Defined Edema,Dizziness,Headache,Malaise,Depression,Hypopigmentation,Bullae formation,Rash,Herpes simplex,Uritcaria,GI disturbances,Leg cramps,Hypotension,Extension of psoriasis

Methoxsalen lotion has been assigned to pregnancy category C by the FDA. Animal reproduction studies have not been conducted with topical methoxsalen, although it has been shown to be a potent photocarcinogen in certain strains of mice. There are no controlled data in human pregnancy. It is also not known to what extent, if any, methoxsalen is absorbed systemically following topical administration. Methoxsalen lotion is only recommended for use during pregnancy when benefit outweighs risk.

Precaution: Patient exhibiting multiple basal cell carcinoma or history of basal cell carcinoma, previous arsenic therapy, previous x-ray or grenz ray therapy; cardiac diseases or those unable to tolerate prolonged standing or exposure to heat stress; GI diseases or chronic infection. Hepatic impairment. Pregnancy and lactation. Lactation: not known whether excreted in breast milk; use caution

In the event of Methoxsalen overdosage, induce emesis and keep the patient in a darkened room for at least 24 hours. Emesis is beneficial only within the first 2 to 3 hours after ingestion of Methoxsalen, since maximum blood levels are reached by this time.

Store at 25°C; excursions permitted to 15°C-30°C.

Methoxsalen preparation

Methoxsalen increases skin reactivity to long-wavelength UV rays. It bonds covalently to DNA inhibiting DNA synthesis and cell division, which can lead to cell injury. This effect is used in photochemotherapy or PUVA and high-intensity long-wavelength UVA irradiation].

Pregnancy Category C. Methoxsalen should be given to a woman only if clearly needed. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Methoxsalen is administered to a nursing woman.