Uses of Viroxi: - Herpes labialis As 5% oint/cream: Apply to the affected skin 5-6 times/day for 5-10 days.

How to use Acyclovir (Topical): This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area. Administration: Probenecid, cimetidine and mycophenolate mofetil may increase the plasma concentration of aciclovir. Increased nephrotoxic effects w/ drugs that affect renal physiology (e.g. ciclosporin, tacrolimus). Adult Dose: Renal impairment. Pregnancy, lactation. Neurological abnormalities with significant hypoxia, serious hepatic or electrolyte abnormalities. Maintain adequate hydration. Lactation: Excretion in milk unknown; systemic exposure is minimal after topical application. Renal Dose: Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes. This active form inhibits viral DNA synthesis and replication by interfering with viral DNA polymerase enzyme and being incorporated into viral DNA.

Hypersensitivity.

Common - Application site reactions (burning, irritation, itching and redness)

Precaution: Herpes virus infections of skin

>10% Burning/stinging (30%) 1-10% Pruritus (4%) <1% Dry lips (<1%),Rash (0.3%) Frequency Not Defined Angioedema,Vulvitis