Tritin 100 mg Tablet

Uses of Tritin: - Pain due to smooth muscle spasm Irritable bowel syndrome, Chronic gastritis Patients with known hypersensitivity to trimebutine maleate or any excipient.

Anticholinergics

Trimebutine maleate is a noncompetitive spasmolytic agent. It possesses moderate opiate receptor affinity and has marked anti-serotonin activity especially on 'mu' receptors. It induces regulation of spontaneous activity and increases synchronization between electrophysiological spikes and contractions in isolated guinea pig strips of colon and ileum. However, it does not alter normal motility, but regulates abnormal intestinal activity.

How to use Trimebutine Maleate: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Trimebutine Maleate may be taken with or without food, but it is better to take it at a fixed time. Administration: May be taken with or without food. Adult Dose: Oral Irritable bowel syndrome Adult: 300-600 mg/day in 3 divided doses. Chronic gastritis Adult: 300 mg/day in 3 divided doses. Elderly: Use with caution.

Trimebutine maleate increases the duration of d-tubocurarine-induced curarization. No other druginteractions have been observed during clinical trial or otherwise reported.

Patients with known hypersensitivity to trimebutine maleate or any excipient.

Common - Palpitations - Increased heart rate - Arrhythmia (irregular heartbeats) - Excessive thirst - Reduce bronchial secretion - Dryness in mouth - Photophobia - Dry skin - Slow heart rate - Loss of accommodation - Flushing (sense of warmth in the face, ears, neck and trunk) - Dilatation of pupil - Difficulty in urination - Constipation Trimebutine Maleate is generally well tolerated. The infrequently reported adverse effects are as follows: a) Gastrointestinal: Dry mouth, foul taste, diarrhea, dyspepsia, epigastric pain, nausea, constipation, b) CNS: Drowsiness, fatigue, dizziness, hot/cold sensations, headache etc.

Although teratological studies have not shown any drug related adverse effects on the course and outcome of pregnancy, the use of trimebutine maleate in pregnant women is not recommended.It is not known if trimebutine maleate passes into breast milk. This medication should be used while breast feeding only if the potential benefits outweigh risks to the nursing infants.

Precaution: Elderly; pregnancy, lactation.

No evidence of overdosage have been reported to date. However, if overdosage should occur following oral administration, gastric lavage is recommended. Treatment should be made according to the symptoms observed.

Store in a cool and dry place, protected from light and moisture. Keep out of the reach of children.

Anticholinergics

Trimebutine is a GI motility regulator with antispasmodic properties.

Although teratological studies have not shown any drug related adverse effects on the course and outcome of pregnancy, the use of trimebutine maleate in pregnant women is not recommended.It is not known if trimebutine maleate passes into breast milk. This medication should be used while breast feeding only if the potential benefits outweigh risks to the nursing infants.

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