Uses of Thiocil: - Hyperthyroidism Hyperthyroidism Hypersensitivity, pregnancy, lactation.

How to use Propyl thio uracil: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Propyl thio uracil may be taken with or without food, but it is better to take it at a fixed time. Administration: Should be taken with food. Adult Dose: Oral Hyperthyroidism Adult: 150-450 mg daily in divided doses. For severe cases, initial doses of 600-1200 mg daily have been used. Maintenance dose for euthyroid patients: 50-150 mg daily. Treatment is usually continued for 1-2 yr. Hepatic impairment: Dose reduction is recommended. Child Dose: Oral Hyperthyroidism Child: Neonates: 2.5-5 mg/kg bid; 1 mth-1 yr: 2.5 mg/kg tid; 1-5 yr: 25 mg tid; 5-12 yr: 50 mg tid; 12-18 yr: 100 mg tid. Renal Dose: Renal impairment: CrCl (ml/min) Dosage Recommendation <10 Reduce dose by 50%. 10-50 Reduce dose by 25%.

May potentiate activity of anticoagulants. Doses of β-blockers, digitalis glycosides and theophylline may need to be reduced when patient becomes euthyroid.

Hypersensitivity, pregnancy, lactation.

Common - Skin rash - Hair loss - Headache - Pain - Joint stiffness - Nausea - Skin pigmentation - Paresthesia (tingling or pricking sensation) Mild leukopenia, lupus-like syndrome, cutaneous vasculitis, thrombocytopenia. Skin rash, urticaria, arthralgia and fever. GI discomfort, vomiting, headache. Potentially Fatal: Agranulocytosis, aplastic anaemia, liver injury and liver failure.

Precaution: Reserve use for patients unable to tolerate any other treatments e.g. methimazole, radioactive iodine or surgery. Inform patient of liver failure risk and to report any signs of liver dysfunction (e.g. loss of appetite, nausea, vomiting, pruritus, dark coloured urine, light coloured stools, jaundice, right upper-quadrant pain) or agranulocytosis (e.g. fever, sore throat) immediately. Stop treatment upon signs of agranulocytosis, aplastic anaemia, fever, liver injury, elevated LFT above 3 times the upper limit of normal, or exfoliative dermatitis. Regular monitoring of thyroid function and CBC is advisable. Monitor prothrombin time regularly during treatment, especially before surgical procedures. Lactation: distributed in breast milk, contraindicated by some sources (AAP Committee states compatible w/ nursing ; AAFP states safe for nursing)

Propylthiouracil inhibits the production of thyroid hormones by preventing iodine from being oxidised in the thyroid gland. It also blocks the peripheral deiodination of thyroxine to tri-iodothyronine.