Insomnia, Premedication in surgery Acute pulmonary insufficiency, resp depression, sleep apnoea, obsessional states, myasthenia gravis, severe hepatic impairment. Pregnancy.

Administration: May be taken with or without food. Gradually taper after extended therapy; abrupt discontinuation should be avoided Adult Dose: Oral Short-term management of insomnia Adult: 7.5-30 mg at bedtime for 7-10 days. Max: 40 mg. Elderly: 5 mg at bedtime. May be increased to 10-20 mg in severe cases. Hepatic impairment: 5 mg at bedtime. May be increased to 10-20 mg in severe cases. Severe: Contraindicated. Premedication in surgery Adult: 20-40 mg, 30 min to 1 hr before the procedure. Elderly: 10-20 mg, 1 hr before the procedure. Hepatic impairment: Severe: Contraindicated. Child Dose: Safety and efficacy not established Renal Dose: Insomnia Renal impairment: 5 mg at bedtime. May be increased to 10-20 mg in severe cases.

May enhance CNS depressant effect w/ Na oxybate, antipsychotics, tranquilisers, neuroleptics, antidepressants, hypnotics, anaesth, analgesics, sedative antihistamines, barbiturates. Effect may be reduced w/ theophylline.

Acute pulmonary insufficiency, resp depression, sleep apnoea, obsessional states, myasthenia gravis, severe hepatic impairment. Pregnancy.

1-10% Drowsiness (9.1%),Dizziness (4.5%),Lethargy (4.5%),Hangover (2.5%),Diarrhea (1.7%),Euphoria (1.5%),Weakness (1.4%),Confusion (1.3%),Vertigo (1.2%) < 1% Amnesia,Angioedema,Blood dyscrasias,Sleep-related behavior (eg, sleep driving, sleep cooking, sleep eating),Ataxia

Precaution: Patient w/ severe depression, chronic pulmonary insufficiency, personality disorders, history of alcohol or drug addiction. Avoid abrupt withdrawal. Renal and hepatic impairment. Elderly or debilitated patient. Lactation. Patient Counselling May impair ability to perform tasks that require alertness (e.g. driving or operating machinery). Monitoring Parameters Monitor resp and CV status. Lactation: Avoid if breastfeeding

Store temazepam at room temperature, 20° to 25°C. Keep temazepam and all medicines out of reach of children.

Benzodiazepine antagonist, Benzodiazepine hypnotics, Benzodiazepine sedatives

Temazepam is a short-acting benzodiazepine w/ anxiolytic, hypnotic/sedative, muscle relaxant properties. It increases neuronal membrane permeability to Cl ions by binding to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron w/in the CNS and enhancing the GABA inhibitory effects resulting in hyperpolarisation and stabilisation.

Pregnancy Category X. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when temazepam is administered to a nursing woman.