Uses of Supermycin: - Bacterial infections Acne, Susceptible infections, Uncomplicated gonorrhoea Hypersensitivity to tetracyclines, children <8 yr, renal damage. Pregnancy, lactation.

Eye Anti-Infectives & Antiseptics, Tetracycline group of drugs, Topical antibiotics for Acne

Oxytetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.

How to use Oxytetracycline: Your doctor or nurse will give you this medicine. Kindly do not self administer. Administration: Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals. Adult Dose: Oral Susceptible infections Adult: 250-500 mg 4 times daily. Max 4 g daily. Acne Adult: 250-500 mg bid. Uncomplicated gonorrhoea Adult: 1.5 g initially, followed by 0.5 g four times daily up to a total of 9 g per treatment course. Intramuscular Susceptible infections Adult: 250 mg once daily or 300 mg daily in 2-3 divided doses. Child Dose: Oral Susceptible infections Child: >8 yr: 25-50 mg/kg daily in 4 divided doses. Intramuscular Susceptible infections Child: >8 yr: 15-25 mg/kg (max 250 mg) daily in 2-3 divided doses. Renal Dose: Renal impairment: Dosage may need to be reduced.

Antacids, iron, aluminum, calcium, magnesium, zinc salts reduce absorption. Concurrent use may cause increased levels of lithium, digoxin, halofantrine and theophylline; decreased concentrations of atovaquone. Increased risk of ergotism with ergot alkaloids. May cause failure of oral contraception. Potentially Fatal: Interferes with anticoagulant control. Nephrotoxic effects exacerbated by diuretics, methoxyflurane or other nephrotoxic drugs; avoid concurrent use with potentially hepatotoxic drugs. Increased incidence of benign intracranial hypertension with retinoids.

Hypersensitivity to tetracyclines, children <8 yr, renal damage. Pregnancy, lactation.

Common - Photosensitivity - Vomiting - Nausea - Diarrhea Anorexia, nausea, vomiting,diarrhoea, glossitis, dysphagia, photosensitivity, oesphageal irritation and ulceration, nephrotoxicity, enterocolitis, rash (rare), blood dyscrasias. Headache, visual disturbances; intracranial hypertension; bulging fontanelles (infants). Potentially Fatal: Rare. Fulminant diarrhoea in post operative patients.

Results of animal studies indicate that tetracyclines cross the placenta, are found in fetal tissues and can have toxic effects on the developing fetus. Evidence of embryotoxicity has also been noted in animals treated early in pregnancy. Tetracyclines are present in the milk of lactating women who are taking a drug in this class.

Precaution: Elderly, renal or hepatic impairment; myasthenia gravis; lupus erythematosus, children <12 yr.

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Eye Anti-Infectives & Antiseptics, Tetracycline group of drugs, Topical antibiotics for Acne

Oxytetracycline binds reversibly to the 30S and possibly 50S ribosomal subunits, thus inhibiting bacterial protein synthesis and arresting cell growth. It is active against a wide range of gram-positive and gram-negative organisms.

Results of animal studies indicate that tetracyclines cross the placenta, are found in fetal tissues and can have toxic effects on the developing fetus. Evidence of embryotoxicity has also been noted in animals treated early in pregnancy. Tetracyclines are present in the milk of lactating women who are taking a drug in this class.