Uses of Stopain:
- Moderate to severe pain
Moderate to severe pain
Head injury; narcotic dependence; respiratory depression; raised intracranial pressure; MI; heart failure; arterial or pulmonary hypertension; porphyria; pregnancy (prolonged use or high doses at term).
Opioid analgesics
Pentazocine is a benzomorphan derivative with mixed opioid agonist and antagonist actions. It alters perception of and response to pain and produces generalised CNS depression by binding to opiate receptors in the CNS and acting as a partial agonist/antagonist.
How to use
Pentazocine Hydrochloride:
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Administration:
Should be taken with food. Take after meals.
Adult Dose:
Oral
Moderate to severe pain
Adult: 50-100 mg every 3-4 hrs; max 600 mg daily.
Hepatic impairment: Reduce dose or avoid in liver disease.
Child Dose:
Oral
Moderate to severe pain
Child: 6-12 yr: 25 mg every 3-4 hr.
Renal Dose:
Renal impairment:
CrCl (ml/min) Dosage Recommendation
10-50 75% normal dose.
<10 50% normal dose.
Depressant affects potentiated by alcohol, CNS depressants; concurrent use with fluoxetine may lead to diaphoresis, ataxia flushing and tremor associated with serotonin syndrome.
Head injury; narcotic dependence; respiratory depression; raised intracranial pressure; MI; heart failure; arterial or pulmonary hypertension; porphyria; pregnancy (prolonged use or high doses at term).
Safe use of Pentazocine during pregnancy (other than labor) has not been established. Animal reproduction studies have not demonstrated teratogenic or embryotoxic effects. However, Pentazocine should be administered to pregnant patients (other than labor) only when, in the judgment of the physician, the potential benefits outweigh the possible hazards. Patients receiving Pentazocine during labor have experienced no adverse effects other than those that occur with commonly used analgesics. Pentazocine should be used with caution in women delivering premature infants.
Precaution:
May precipitate withdrawal in narcotic addicts. Impaired respiratory, renal and hepatic function; morbidly obese patients; thyroid dysfunction; prostatic hyperplasia or urinary stricture; biliary tract impairment; adrenal insufficiency (including Addison's disease); abdominal conditions. Elderly or debilitated patients; seizure-prone patients; children and infants (safety and efficacy not established in <1 yr); lactation. May impair ability to drive or operate machinery. Administer IM rather than SC (when frequent inj are needed) and inj sites should be varied.
Lactation: unknown if excreted in breast milk, use caution
Pentazocine is a benzomorphan derivative with mixed opioid agonist and antagonist actions. It alters perception of and response to pain and produces generalised CNS depression by binding to opiate receptors in the CNS and acting as a partial agonist/antagonist.
Pregnancy Category: C; D if used for prolonged periods or near term
