Slipam 15 mg Capsule

Uses of Slipam: - Insomnia Insomnia Hypersensitivity; porphyria. Pregnancy (3rd trimester); neonates.

Benzodiazepine hypnotics

Flurazepam is a long-acting benzodiazepine which binds to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron w/in the CNS, including the limbic system, reticular formation. It enhances the inhibitory effect of GABA on neuronal excitability by increasing neuronal membrane permeability to Cl ions, thus resulting in hyperpolarisation and stabilisation.

How to use Flurazepam: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Flurazepam may be taken with or without food, but it is better to take it at a fixed time. Administration: May be taken with or without food. Adult Dose: Oral Short-term management of insomnia Adult: 15-30 mg at night. Elderly: Max: 15 mg at night. Child Dose: Oral Short-term management of insomnia Child: >15 yr 15 mg at night. Elderly: Max: 15 mg at night.

May enhance CNS depressant effect w/ antidepressants, antipsychotics, general anaesth, hypnotics or sedatives, opioid analgesics. Flurazepam clearance may be reduced by cimetidine, and may be increased by rifampicin.

Hypersensitivity; porphyria. Pregnancy (3rd trimester); neonates.

Common - Dizziness - Drowsiness - Impaired coordination - Lightheadedness Common Ataxia,Dizziness,Drowsiness,Lethargy,Light-headedness Less Common Chest pain, palpitations,Headache, irritability, nervousness, weakness,GI complaints,Myalgia,GU complaints Rare Elevations of AST, ALT, bilirubin (T&D), alk phos

Category X: Studies in animals or human beings have demonstrated fetal abnormalities or there is evidence of fetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.

Precaution: Chronic pulmonary insufficiency; elderly or debilitated patients; muscle weakness, impaired liver or kidney function; drowsiness may affect skilled tasks; monitor cardio-respiratory function when used for deep sedation; personality disorders or organic brain changes; history of alcohol or drug addiction. Respiratory depression and hypotension with parenteral admin. Dependence; lactation. Safety and efficacy are not proven in children <15 yr. Lactation: Excretion in milk unknown; not recommended

Flurazepam overdosage includes somnolence, confusion and coma. Respiration, pulse and blood pressure should be monitored as in all cases of drug overdosage. General supportive measures should be employed, along with immediate gastric lavage.

Capsules should be stored in a dry place at 20°-25°C temperature.

Benzodiazepine hypnotics

Flurazepam is a long-acting benzodiazepine which binds to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron w/in the CNS, including the limbic system, reticular formation. It enhances the inhibitory effect of GABA on neuronal excitability by increasing neuronal membrane permeability to Cl ions, thus resulting in hyperpolarisation and stabilisation.

Pregnancy Category: X Lactation: Excretion in milk unknown; not recommended Minor tranquilizers should be avoided in 1st trimester of pregnancy due to increased risk of congenital malformations Maternal use shortly before delivery is associated with floppy infant syndrome (good and consistent evidence) Prenatal benzodiazepine exposure slightly increased oral cleft risk (limited or inconsistent evidence)

Related Medicines

Save Medicine to Collection

Slipam 15 mg

Create New Collection