Rutix tablets are indicated for the treatment of adults with mild to moderate infections caused by susceptible strains. Lower Respiratory Tract: Acute bacterial exacerbation of chronic bronchitis lung abscess, pneumonia. Gastrointestinal Tract: Enteric fever, shigellosis. ... Read moreRutix tablets are indicated for the treatment of adults with mild to moderate infections caused by susceptible strains. Lower Respiratory Tract: Acute bacterial exacerbation of chronic bronchitis lung abscess, pneumonia. Gastrointestinal Tract: Enteric fever, shigellosis. Multi-drug-resistant Tuberculosis. Skin and skin structures: Uncomplicated skin and skin structure infections. Sexually Transmitted Diseases: Acute, Uncomplicated urethral and cervical gonorrhoea. Nongonococcal urethritis and cervicitis. Mixed infections of the urethra and cervix. Urinary tract: Uncomplicated Urinary Tract Infections, Complicated urinary tract infections. Rutix Eye & Ear Drops is indicated in- Eye: It is indicated for the treatment of external ocular infections such as acute & sub-acute conjunctivitis, keratitis, kerato-conjunctivitis, blepharo-conjunctivitis, blepharitis, corneal ulcer and pre-operative prophylaxis in ocular surgery. Ear: It is indicated for the treatment of external ear infections (otitis externa) and certain middle ear infections (otitis media).

4-Quinolone preparations, Aural Anti-bacterial preparations

Ofloxacin is a synthetic 4-fluoroquinolone antibacterial agent with bactericidal activity against a wide range of Gram-negative and Gram-positive organisms. Ofloxacin is thought to exert bactericidal effect by inhibiting DNA gyrase, an essential enzyme that is a critical catalyst in the duplication, transcription and repair of bacterial DNA.

Antacids containing magnesium, aluminium or calcium may decrease absorption of ofloxacin. Iron or Zinc may decrease oral absorption of ofloxacin.

Ofloxacin should not be used in-patients with known hypersensitivity to 4-fluoroquinolone antibacterials. It is contraindicated in-patients with a history of epilepsy or with a lowered seizure threshold. Ofloxacin is usually contraindicated in children or growing adolescents and in pregnant or breast feeding women.

Ofloxacin tablet is generally well tolerated and clinical side-effects of ofloxacin has been quite low. Among the adverse effects gastrointestinal and central nervous systems' reactions are common. Nausea, rash, vomiting, abdominal pain, diarrhoea and gastrointestinal distress are the gastrointestinal adverse effects. Common central nervous system reactions are headache, dizziness and insomnia.Eye: Transient ocular irritation, burning, stinging, redness, itching or photophobia have been reported.Ear: Mild irritation or mild discomfort in the ear may occur. Symptoms of an allergic reaction include rash, itching, swelling or trouble breathing.

The safety of ofloxacin during pregnancy has not been established. Ofloxacin may enter breast milk but data are not available.

Patients being treated with Ofloxacin should not expose themselves unnecessarily to strong sunlight and should avoid UV rays. Caution is recommended if the drug is to be used in psychotic patients or in-patients with a history of psychiatric disease.Prolonged use of eye drops & ear drops may result in overgrowth of non-susceptible organisms and secondary infection respectively.

Symptoms: Confusion, dizziness, impairment of consciousness, convulsive seizures, GI reactions (e.g. nausea, mucosal erosions). Management: Symptomatic and supportive treatment. Remove any unabsorbed drug by gastric lavage or admin of adsorbants and Na sulfate. Antacids are recommended for protection of gastric mucosa. Elimination may be increased by forced diuresis.

Store between 15-30°C. Protect from light.

4-Quinolone preparations, Aural Anti-bacterial preparations

Ofloxacin containing ofloxacin is a synthetic 4-fluoroquinolone antibacterial agent with bactericidal activity against a wide range of Gram-negative and Gram-positive organisms. Ofloxacin is thought to exert bactericidal effect by inhibiting DNA gyrase, an essential enzyme that is a critical catalyst in the duplication, transcription and repair of bacterial DNA. Following oral administration ofloxacin is rapidly and well absorbed from G.I. tract. The bioavailability of ofloxacin in the tablet formulation is almost 100%. It is widely distributed into body tissues and fluid. The half-life is about 4.6 to 6.9 hours. Up to 80% of an oral dose of ofloxacin is eliminated in the urine as the parent compound within 48 hour.

The safety of ofloxacin during pregnancy has not been established. Ofloxacin may enter breast milk but data are not available.