Relaxo 50 mg
Dantrolene Sodium
Category: Capsule
Manufacturer: Ziska Pharmaceuticals Ltd.
Allopathic
MFG. Licence No. Biological
183
MFG. Licence No. Non-Biological
424
Address
Karol Surichala, Shafipur, Kaliakoir, Gazipur
Price: 360.0 ৳
24's pack
6's Strip
piece
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Related Medicines
Muscle tightness, muscle cramping (spasms), muscle pain caused by spinal cord injury, stroke, cerebral palsy, multiple sclerosis.
Active liver disease; acute muscle spasm; patients who use their spasticity to maintain posture or function. Lactation.
Centrally acting Skeletal Muscle Relaxants
Dantrolene produces relaxation by affecting the contractile response of the skeletal muscle. In skeletal muscle, Dantrolene dissociates the excitation-contraction coupling, probably by interfering with the release of Ca++ from the sarcoplasmic reticulum.
Administration:
May be taken with or without food.
Adult Dose:
Oral
Spasticity
Adult: Initially, 25 mg daily increased gradually at 7-day intervals over 7 wk. Discontinue if no response after 45 days of treatment. Max: 100 mg 4 times daily.
Child Dose:
Oral
Spasticity
Child: Initially, 0.5 mg/kg once daily, may increase gradually to 2 mg/kg 3-4 times daily. Max: 100 mg 4 times daily.
CNS depressants; oestrogens; calcium-channel blockers. CNS effects enhanced by alcohol or CNS depressants.
Active liver disease; acute muscle spasm; patients who use their spasticity to maintain posture or function. Lactation.
Fatigue, muscle weakness/pain. GI disturbances, CNS effects, tachycardia, unstable BP, dyspnoea, drowsiness, rashes, pruritus, chills and fever, visual disturbances, dysphagia, speech disturbances; haematuria, crystalluria, urinary frequency, retention and incontinence. Increased serum AST (SGOT), ALT (SGPT), alkaline phosphatase, LDH, BUN, and total serum bilirubin concentrations, Difficult erection, Abnormal hair growth, Aplastic anemia, Anemia, Leukopenia, Lymphoma, Thrombocytopenia
Potentially Fatal: Hepatotoxicity, pleural effusion with pericarditis.
Pregnancy Category C. Dantrolene should not be used in nursing mothers.
Precaution:
Perform LFTs before and during treatment. Increased risk of liver injury in patients >30 yr, female patients especially those on oestrogen therapy, history of liver disease or patients with daily dose >400 mg. Cardiac or pulmonary disorders. Pregnancy.
Lactation: enters breast milk/not recommended
Store in a cool & dry place, protected from light.
Centrally acting Skeletal Muscle Relaxants
Dantrolene has a direct action on skeletal muscle. It uncouples muscular contraction from excitation, probably by interfering with calcium release from sarcoplasmic reticulum.
Pregnancy Category: C
Lactation: enters breast milk/not recommended
Samm Care