Uses of Receptin: - Gastroesophageal reflux disease (Acid reflux) - Peptic ulcer disease Heartburn, Dyspepsia, Peptic ulcers, Benign gastric and duodenal ulceration, Gastro-oesophageal reflux disease, Zollinger-Ellison syndrome, Pancreatic insufficiency Hypersensitivity, lactation.

How to use Cimetidine: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cimetidine may be taken with or without food, but it is better to take it at a fixed time. Administration: IV Preparation Solution Injections: in 5% sodium bicarbonate injection, NS, D5W, D10W or LR to a volume of 20 mL Infusions: 300 mg in 100 mL D5W IV Administration Slow direct IV injection over 5 min or more after dilution to a total of 20 mL with compatible diluent (NS), OR Intermittent IV infusion over 15 to 20 min in at least 50 mL of compatible diluent, OR Continuous IV infusion in 100 to 1000 mL of compatible diluent over 24 hr Adult Dose: Intravenous Benign gastric and duodenal ulceration Adult: Intermittent infusion: 300 mg 6-8 hrly infused over 15-20 min. Max: 2400 mg/day. Continuous infusion: 37.5 mg/hr (900 mg/day). A 150 mg IV loading dose may be given in patients requiring rapid elevation of gastric pH. Zollinger-Ellison syndrome Adult: Intermittent infusion: 300 mg 6-8 hrly infused over 15-20 min. Max: 2400 mg/day. Continuous infusion: 37.5 mg/hr (900 mg/day). A 150 mg IV loading dose may be given in patients requiring rapid elevation of gastric pH. Renal Dose: Renal Impairment CrCl<30 mL/min 300 mg IV/IO q12hr Prevention of upper GI bleeding: 25 mg/hour continuous IV infusion

Reduces absorption of dasatinib, ketoconazole, itraconazole and posaconazole. May increase serum levels of phenytoin, theophylline, lidocaine, hydroxyzine and oral anticoagulants. Absorption may be reduced by antacids. Decreased bioavailability w/ metoclopramide, sucralfate or propantheline. May potentiate the myelosuppressive effects (e.g. agranulocytosis, neutropenia) of myelosuppressive drugs (e.g. antimetabolites, alkylating agents) or therapies (e.g. radiation).

Hypersensitivity, lactation.

Common - Headache - Diarrhea - Muscle pain - Skin rash - Tiredness 1-10% Headache (2.1%),Dizziness (1%),Somnolence (1%),Gynecomastia (0.3-4%) Frequency Not Defined Confusion (elderly),Impotence,Diarrhea,Nausea,Vomiting

Precaution: Impaired renal and hepatic function. Age >50 yr; CV impairment. Pregnancy. Lactation: enters breast milk/not recommended

Cimetidine competitively inhibits histamine at H2-receptors of the gastric parietal cells resulting in decreased gastric acid secretion, gastric volume and hydrogen ion concentration. It is also used in patients w/ pancreatic insufficiency to reduce the breakdown of pancreatic enzyme supplements.

Pregnancy Category: B Lactation: enters breast milk/not recommended