Uses of Protogyn: - Bacterial infections - Parasitic infections Giardiasis, H. pylori infection, Surgical Prophylaxis, Bacterial vaginosis, Intestinal amoebiasis, Trichomoniasis, Acute necrotising ulcerative gingivitis, Hepatic amoebiasis Blood dyscrasias, organic neurologic disorders, hypersensitivity to 5-nitroimidazole derivatives, porphyria. Lactation, pregnancy (1st trimester).

Amoebicides

Tinidazole, a 5-nitroimidazole derivative with antimicrobial actions similar to metronidazole, is active against both protozoa (e.g. Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia) and obligate anaerobic bacteria. It damages DNA strands or inhibits DNA synthesis in microorganism.

How to use Tinidazole: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tinidazole is to be taken with food. Administration: Should be taken with food. Take during or immediately after meals. Adult Dose: Oral Bacterial vaginosis Adult: 2 g as single dose. May also be given as 2 g for 2 consecutive days or 1 g daily for 5 days. Anaerobic bacterial infections Adult: 2 g on the 1st day, followed by 1 g daily or 500 mg bid for 5-6 days. Prophylaxis of postoperative anaerobic bacterial infections Adult: 2 g as single dose 12 hr before surgery. Eradication of H. pylori associated with peptic ulcer disease Adult: 500 mg bid, given w/ clarithromycin and omeprazole for 7 days. Intestinal amoebiasis Adult: 2 g daily for 2 or 3 days. Hepatic amoebiasis Adult: 1.5-2 g daily for 3-6 days. Giardiasis Adult: 2 g as single dose. Trichomoniasis; Acute necrotising ulcerative gingivitis Adult: 2 g as single dose. In trichomoniasis, sexual partners should be treated at the same time. Intravenous IV Susceptible infections Initial: Infuse 800 mg, followed by 800 mg/day or 400 mg twice daily till PO can be given. Surgical prophylaxis 1.6 g as single infusion pre-op. Child Dose: Oral Intestinal amoebiasis Child: >3 yr 50-60 mg/kg daily for 3 consecutive days. Max: 2 g/day. Hepatic amoebiasis Child: >3 yr 50-60 mg/kg daily for 5 days. Max: 2 g/day. Giardiasis Child: >3 yr 50-75 mg/kg as single dose, repeat if necessary. Max: 2 g/day. Renal Dose: Renal impairment: Haemodialysis: Additional dose equal to half the usual dose at the end of haemodialysis.

May potentiate the effects of oral anticoagulants resulting to prolonged prothrombin time.

Blood dyscrasias, organic neurologic disorders, hypersensitivity to 5-nitroimidazole derivatives, porphyria. Lactation, pregnancy (1st trimester).

Common - Headache - Dryness in mouth - Nausea - Metallic taste 1-10% Anorexia (2-3%),Constipation (<1%),Dizziness (<1%),Dysgeusia (4-6%),Dyspepsia (1-2%),Headache (<1%),Nausea (3-5%),Vomiting (1-2%),Weakness/fatigue/malaise (1-2%) Frequency Not Defined Ataxia,Candida overgrowth,Convulsions & transient peripheral neuropathy,Numbness & paresthesia,Diarrhea,Darkened urine,Tongue discoloration,Transient leukopenia/neutropenia Potentially Fatal: Hypersensitivity.

Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Precaution: Patient w/ current or a history of blood dyscrasias. Pregnancy (2nd and 3rd trimester). Hepatic and renal impairment. Monitoring Parameters Monitor total and differential leukocyte counts. Closely monitor childn when treatment duration exceeds 3 days. Lactation: discontinue nursing while taking drug & for 3 d after last dose

Store at room temperature & protected from light.

Amoebicides

Tinidazole, a 5-nitroimidazole derivative w/ antimicrobial actions similar to metronidazole, is active against both protozoa (e.g. Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia) and obligate anaerobic bacteria. It damages DNA strands or inhibits DNA synthesis in microorganism.

Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.