Uses of P Phos: - Malaria Malaria Hypersensitivity. Childn <1 yr. Acute flare-ups of systemic diseases (RA, SLE) having tendency for agranulocytopaenia, Pregnancy and lactation.

How to use Primaquine: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Primaquine is to be taken with food. Administration: Should be taken with food. Take w/ meals to avoid GI discomfort. Adult Dose: Oral Prevention of relapse of P. vivax malaria 30 mg PO qDay for 14 days Uncomplicated P. vivax and P. ovale malaria 30 mg PO qDay for 14 days with chloroquine or hydroxychloroquine Alternatively, for mild G6PD deficiency or as alternative to daily regimen: 45 mg PO qDay for 8 weeks (only to be used after consultation with an infectious disease/tropical medicine expert Chemoprophylaxis P. vivax and P. ovale maleria: 30 mg PO qDay for 14 days after departure from malaria-endemic area Child Dose: Oral Uncomplicated P. vivax and P. ovale malaria 0.5 mg/kg (30 mg/day maximum) qDay for 14 days with chloroquine or hydroxychloroquine Chemoprophylaxis 0.5 mg/kg PO qDay (30 mg/day maximum); start 1-2 days prior to travel and continue for 7 days after departure from malaria endemic area

Primaquine may inhibit metabolism of chloroquine. Avoid ethanol. Potentially Fatal: Mepacrine may potentiate toxicity of primaquine. Potentially haemolytic drugs eg, sulphonamides, nitrofurans and bone marrow suppressants eg, methotrexate, phenylbutazone, chloramphenicol should not be co-admin with primaquine.

Hypersensitivity. Childn <1 yr. Acute flare-ups of systemic diseases (RA, SLE) having tendency for agranulocytopaenia, Pregnancy and lactation.

Common - Rash - Vomiting - Headache - Dizziness - Hives - Stomach pain - Nausea - Abdominal pain - Itching - Heartburn - Gastrointestinal discomfort - Upper abdominal pain >10% Abdominal pain,Hemolytic anemia in G6PD deficiency,Nausea,Vomiting <1-10% Methemoglobinemia in NADH-methemoglobin reductase-deficient individuals <1% Agranulocytosis,Arrhythmias,Headache,Interference with visual accommodation,Leukopenia,Leukocytosis,Rash,Dizziness,Pruritus Potentially Fatal: Haemolytic anaemia (G6PD deficient), thrombocytopaenia, leucopaenia, AV block.

Precaution: G6PD deficiency; pregnancy; NADH methaemoglobin reductase deficient patients. Monitor Hb levels and blood counts routinely. Patients with systemic diseases that have an increased risk of granulocytopenia. Withdraw treatment if signs of haemolysis or methaemogloinaemia occur.

Primaquine is an 8-aminoquinoline antimalarial which eliminates the exoerythrocytic forms of malarial parasite P.vivax, P. falciparum by disrupting mitochondria and binding to DNA. By this action primaquine achieves radical cure of vivax malaria. It is also active against gametocytes of P.falciparum.