Uses of Opsophenicol: - Bacterial infections Tetracycline-resistant cholera, typhoid, brain abscesses, meningitis, Granuloma inguinale, Anthrax, Listeriosis, Gas gangrene, Whipple's disease, gastroenteritis, melioidosis, Plague, Psittacosis, Q fever, Tularaemia History of hypersensitivity or toxic reaction to the drug; pregnancy, lactation; porphyria; parenteral admin for minor infections or as prophylaxis; preexisting bone marrow depression or blood dyscrasias.

Ear Anti-Infectives & Antiseptics, Eye Anti-Infectives & Antiseptics, Macrolides

Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.

How to use Chloramphenicol: Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Chloramphenicol is to be taken empty stomach. Administration: Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals. Adult Dose: Adult: PO Susceptible infections 50 mg/kg/day in 4 divided doses, may increase to 100 mg/kg/day in more severe infections. Hepatic impairment: Dose reduction may be required. Child Dose: PO Susceptible infections Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50-75 mg/kg/day in 4 divided doses increased to 75-100 mg/kg/day for meningitis or severe infections. Renal Dose: Renal impairment: Dose reduction may be required.

Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of oral contraceptives. Potentially Fatal: Increases the effect of oral anticoagulants, oral hypoglycaemic agents, phenytoin. Avoid concomitant administration with drugs that depress bone marrow function.

History of hypersensitivity or toxic reaction to the drug; pregnancy, lactation; porphyria; parenteral admin for minor infections or as prophylaxis; preexisting bone marrow depression or blood dyscrasias.

Common - Vomiting - Nausea - Diarrhea - Taste change <1% Nightmares,Headache,Rash,Diarrhea,Stomatitis,Enterocolitis,Nausea,Vomiting,Bone marrow suppression,Aplastic anemia,Peripheral neuropathy,Optic neuritis,Gray syndrome Potentially Fatal: Bone marrow suppression and irreversible aplastic anaemia. Neutropenia, thrombocytopenia. Grey baby syndrome. Rarely, anaphylaxis.

Pregnancy Category C. Either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus.

Precaution: Impaired renal or hepatic function; premature and full-term neonates. Monitor plasma concentrations to avoid toxicity. Lactation: enters breast milk; discontinue drug or do not nurse

Cap/susp: Store at temp not exceeding 30°C. Ophth/otic preparation: Store between 2-8°C. Do not freeze. Protect from light.

Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.

Pregnancy Category: C Lactation: enters breast milk; discontinue drug or do not nurse