Uses of Nystat: - Fungal skin infections Fungal infections, Oropharyngeal candidiasis, Intestinal candidiasis, Vaginal candidiasis Hypersensitivity.

Drugs for subcutaneous and mycoses, Drugs used in Vaginal and Vulval condition

Nystatin has fungistatic or fungicidal activity against variety of pathogenic and nonpathogenic yeast and fungi, including Candida albicans. Nystatin exerts its antifungal activity by binding to sterols in the fungal cell membrane. As a result of binding, the membrane is no longer able to function as a selective barrier, and potassium and other cellular constituents are lost. It is poorly absorbed from the gastrointestinal tract.

How to use Nystatin: This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and gently massage the ointment. Administration: May be taken with or without food. Adult Dose: Oral Oral candidiasis Adult: As oral susp or drop : 100,000-600,000 U (1-6 ml drop) into the mouth 4 times daily. Keep in contact w/ affected area as long as possible. Continue for 48 hr after clinical cure to prevent relapse. Intestinal candidiasis Adult: As tab or oral susp/drop: 500,000 or 1,000,000 U 3-4 times daily. Prophylaxis: 1,000,000 U daily. Vaginal Vulvovaginal candidiasis Adult: insert 1 vaginal tablet into vagina daily at bedtime for 14 days or longer. Child Dose: As oral susp or drop Infants: PO: 2 mL/dose, children 4–6 mL/dose, to coat oral mucosa q6h As tab Child: PO: 3–6 tabs/day tid For prophylaxis of oral candidiasis in the newborn the suggested dose is 1 ml (100,000 U) once daily. Administration should be continued for 48 hours after clinical cure to prevent relapse.

Hypersensitivity.

Common - Application site reactions (burning, irritation, itching and redness) Nausea, vomiting, diarrhoea, GI upset, oral irritation and sensitisation. Rarely, rash, urticaria, Stevens-Johnson syndrome, tachycardia, bronchospasm, facial swelling, nonspecific myalgia Vaginal tablet: May damage latex contraceptives (e.g. diaphragms, condoms), additional contraceptive measures should be taken. Localized sensitization.

Mouth/Throat/PO/Topical: Pregnancy catagory CVaginal: Pregnancy catagory A

Precaution: Immunocompromised patients. Childn. Pregnancy and lactation. Patient Counselling May damage latex contraceptives (vag). Lactation: Not known if excreted in breast milk; use caution

Store in a cool and dry place, protect from light. Keep out of reach of children.

Nystatin, a polyene antifungal, binds to ergosterol in the fungal cell membrane. This binding affects the cell wall permeability allowing leakage of cellular contents.

Pregnancy category: C, ROUTE(S) : Mouth/Throat / PO Pregnancy Category: A, ROUTE(S) : Vaginal