Uses of Norbit: - Arrhythmia Ventricular tachycardia, Supraventricular arrhythmias,Ventricular arrhythmias Patients with complete heart block; glaucoma; predisposition to urinary retention; myasthenia gravis. Sinus node disease in absence of pacemaker. Cardiomyopathy. Cardiogenic shock. Hypotension. Hypersensitivity. Children.

How to use Disopyramide: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Disopyramide is to be taken empty stomach. Adult Dose: Oral Supraventricular and ventricular arrhythmias Adult: 300-800 mg daily in divided doses (as conventional capsules every 6 hr), adjusted according to patient's response. Hepatic impairment: 400 mg daily in divided doses. Liver cirrhosis: consider a therapeutic range 50% lower than in patients with normal hepatic function. Child Dose: Oral Ventricular Arrhythmias <1 year old: 10-30 mg/kg/day divided q6hr PO 1-4 years old: 10-20 mg/kg/day divided q6hr PO 4-12 years old: 10-15 mg/kg/day divided q6hr PO 12-18 years old: 6-15 mg/kg/day divided q6hr PO Renal Dose: Renal impairment: CrCl (ml/min) >40 400 mg daily in divided doses. 30-40 100 mg every 8 hr; avoid modified release preparations. 15-30 100 mg every 12 hr; avoid modified release preparations. <15 100 mg every 24 hr; avoid modified release preparations.

Avoid other Class I antiarrhythmics and other cardiac depressants including beta-blockers except in life-threatening arrhythmias. Risk of worsening of arrhythmias, precipitation of new arrhythmias and ventricular fibrillation when used with other anti-arrhythmics. Reduced efficacy when co-admin with phenytoin. Potentially Fatal: Enhanced antimuscarinic effects with other antimuscarinic drugs. Potentiates negative chronotropic and inotropic effects of ?-blockers and verapamil. Potentiates inhibitory effect on the conduction system produced by digitalis. Potentiates QT interval prolongation produced by TCAs and amiodarone.

Patients with complete heart block; glaucoma; predisposition to urinary retention; myasthenia gravis. Sinus node disease in absence of pacemaker. Cardiomyopathy. Cardiogenic shock. Hypotension. Hypersensitivity. Children.

Common - Blurred vision - Worsening of pre-existing glaucoma - Constipation - Dryness in mouth - Urinary retention >10% Xerostomia (32%),Urinary hesitancy (23%),Constipation (11%) 1-10% Impotence,Urinary urgency,Urinary retention,Dry throat,Weight gain,Abdominal distension,Flatulence,Anorexia,Vomiting,Nausea,Dermatoses,Pruritus,Generalized rash,Increased triglycerides and cholesterol,Hypokalemia,Muscle weakness,Muscular pain,Dyspnea,Blurred vision,Dry eyes,Fatigue,Malaise,Headache,Dizziness,Nervousness,Syncope,Hypotension,Chest pain,Edema <1% AV block,Hypoglycemia (rare),Agranulocytosis,Respiratory distress,Creatinine increased,Psychotic reaction,Paresthesia,Lupus (rare),Peripheral neuropathy,Insomnia Potentially Fatal: Urinary retention, severe cardiovascular depression if given as rapid IV inj. High risk of recurrence of failure in patients with history of congestive cardiac failure. Negative inotropic effect especially prominent in patients with cardiomyopathy, hypertension and uncompensated cardiac failure.

Precaution: Conduction disorders or uncompensated heart failure. Pregnancy and lactation. Renal and hepatic failure. Family history of glaucoma. Correct potassium deficiency. Lactation: crosses into breast milk, discontinue drug or do not nurse

Disopyramide is a Ia antiarrhythmic agent which acts by decreasing myocardial excitability and conduction velocity. It lengthens the effective refractory period of the atrium. It also possesses antimuscarinic and negative inotropic effects.