Nopik 120 mg Tablet

    Nopik 120 mg

    Nateglinide

    Category: Tablet

    Manufacturer: Square Pharmaceuticals PLC, Pabna

    Uses of Nopik: - Type 2 diabetes mellitus Type 2 DM Diabetic ketoacidosis; IDDM. Lactation.
    Meglitinide Analogues
    Nateglinide, a nonsulfonylurea hypoglycaemic agent which stimulates insulin release from the pancreatic β-cells by blocking ATP-dependent K channels, depolarising the membrane and facilitating Ca entry through Ca channels. This action depends on the amount of existing glucose levels.
    How to use Nateglinide: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nateglinide is to be taken empty stomach. Administration: Take immediately before or up to ½ hr before meals. Adult Dose: Oral Type 2 diabetes mellitus Adult: 60 or 120 mg tid.
    Increased levels/effects with enzyme inhibitors (e.g. fluconazole). Increased hypoglycaemic effects with salicylates, MAOIs, nonselective beta-blockers, alcohol, NSAIDs. Decreased levels/effects with enzyme inducers (e.g. rifampicin). Decreased hypoglycaemic effects with thiazide diuretics, corticosteroids, thyroid products and sympathomimetic agents.
    Diabetic ketoacidosis; IDDM. Lactation.
    Common - Hypoglycemia (low blood glucose level) - Dizziness - Increased appetite - Increased heart rate - Nausea - Sweating - Tiredness - Weakness 1-10% Increased uric acid (10%),Dizziness (4%),Arthropathy (3%),Flu-like syndrome,Weight gain,Hypoglycemia (2%) Frequency Not Defined Diarrhea,Nausea
    Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
    Precaution: Geriatric patients, debilitated and malnourished patients; adrenal or pituitary insufficiency, moderate to severe hepatic impairment; severe renal impairment. Monitor glycaemic levels during periods of stress. Pregnancy. Lactation: unsafe
    Symptoms: Hypoglycaemia. Management: Use IV glucose in severe reaction.
    Store at 25° C.
    Meglitinide Analogues
    Nateglinide, a nonsulfonylurea hypoglycaemic agent, acts by stimulating insulin release from pancreatic ?-cells to reduce postprandial hyperglycaemia. This action depends on the amount of existing glucose levels.
    Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
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