Nimoral 30 mg
Nimodipine
Category: Tablet
Manufacturer: Drug International Ltd.
Allopathic
MFG. Licence No. Biological
398
MFG. Licence No. Non-Biological
127
Address
Tongi I/A, Gazipur
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Related Medicines
Uses of Nimoral:
- Subarachnoid haemorrhage
Subarachnoid haemorrhage, Stroke prevention
Use w/in 1 mth of MI or an episode of unstable angina. Concomitant use w/ potent CYP3A4 inhibitors (e.g. clarithromycin, ritonavir, ketoconazole, nefazodone).
Calcium-channel blockers
Nimodipine inhibits inflow of Calcium ions into cells by blocking Calcium channels or select voltage-sensitive areas resulting in relaxation of vascular smooth muscle and myocardium during depolarisation. Nimodipine has greater action on the cerebral vessels because of its high lipophilicity.
How to use Nimodipine:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nimodipine may be taken with or without food, but it is better to take it at a fixed time.
Administration:
Cap: Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Tab: May be taken with or without food. Take consistently, either always w/ or always w/o meals.
Adult Dose:
Oral
Prophylaxis of neurological deficit following subarachnoid haemorrhage
Adult: 60 mg 4 hrly beginning w/in 4 days of onset of haemorrhage and continued for 21 consecutive days.
Hepatic impairment: Initially, 30 mg 4 hrly.
Plasma concentration and efficacy may be significantly reduced when administered w/ strong CYP3A4 inducers (e.g. rifampicin, carbamazepine, phenobarbital, phenytoin). May increase serum levels and toxicity of phenytoin. Increased plasma concentrations w/ cimetidine or sodium valproate.
Potentially Fatal: Increased risk of significant hypotension w/ concomitant potent CYP3A4 inhibitors (e.g. clarithromycin, ritonavir, ketoconazole, nefazodone).
Use w/in 1 mth of MI or an episode of unstable angina. Concomitant use w/ potent CYP3A4 inhibitors (e.g. clarithromycin, ritonavir, ketoconazole, nefazodone).
Common
- Decreased blood pressure
- Headache
- Increased heart rate
- Nausea
- Rash
- Stomach discomfort
- Edema (swelling)
- Muscle cramp
1-10%
Reduction in systemic blood pressure (1-8%),Diarrhea (2-4%),Headache (1-4%),Abdominal discomfort (2%),Rash (1-2%)
<1%
Heart failure,Arrhythmia,Anemia,ECG abnormalities,GI hemorrhage,Hepatitis,Jaundice,Thrombocytopenia,Vomiting,Thrombosis,Rebound vasospasm
Potentially Fatal: Angina/MI, symptomatic hypotension.
Use in Pregnancy: Large doses of nimodipine have been shown to cause birth defects in animals. Human studies have not been done. Before you take nimodipine, tell your doctor if you are pregnant or plan to become pregnant.Use in Nursing Mothers: Nimodipine may pass into breast milk but has not been reported to cause problems; caution is advised. Consult your doctor for advice.
Precaution:
Patients w/ cerebral oedema or severely raised intracranial pressure. Contents of oral capsules should be given only by mouth or through a feeding tube. It must never be administered IV or by any other parenteral route. Hepatic and renal impairment. Pregnancy and lactation. Monitoring Parameters Careful monitoring of BP and pulse rate.
Lactation: unknown; avoid
Symptoms: Excessive peripheral vasodilation, systemic hypotension, tachycardia, bradycardia, GI complaints, nausea. Management: Symptomatic and supportive treatment. Admin of vasopressor may be necessary if significant hypotension occurs. IV Ca salts have been also used for hypotension.
Store between 15-30° C. Protect from light.
Calcium-channel blockers
Nimodipine inhibits inflow of Ca ions into cells by blocking Ca channels or select voltage-sensitive areas resulting in relaxation of vascular smooth muscle and myocardium during depolarisation. Nimodipine has greater action on the cerebral vessels because of its high lipophilicity.
Use in Pregnancy: Large doses of nimodipine have been shown to cause birth defects in animals. Human studies have not been done. Before you take nimodipine, tell your doctor if you are pregnant or plan to become pregnant.Use in Nursing Mothers: Nimodipine may pass into breast milk but has not been reported to cause problems; caution is advised. Consult your doctor for advice.
Samm Care