Monotrate 50 mg
Isosorbide Mononitrate
Category: Tablet
Manufacturer: Sun Pharmaceutical (Bangladesh) Ltd.
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Related Medicines
Uses of Monotrate:
- Angina (heart-related chest pain)
Angina pectoris
Severe hypotension or anaemia, hypovolaemia, heart failure due to obstruction, or raised intracranial pressure due to head trauma or cerebral haemorrhage.
Nitrates: Coronary vasodilators
Isosorbide mononitrate relaxes vascular smooth muscles by stimulating cyclic-GMP. It decreases left ventricular pressure (preload) and arterial resistance (afterload).
How to use
Isosorbide Mononitrate:
Use it as advised by your doctor or check the label for directions before use.
Isosorbide Mononitrate is to be taken empty stomach.
Administration:
Should be taken on an empty stomach (i.e. At least one hour before food or two hours after food).
Adult Dose:
Oral
Angina Pectoris
Prevention of angina pectoris caused by coronary artery disease
Adult: 20 mg 2-3 times daily. Dose may range from 20-120 mg daily.
As LA form: One capsule once daily.
Elderly: Intiate at lower doses.
Child Dose:
Safety and efficacy not established
Hypotensive effects may be increased when used with alcohol or vasodilators. Concurrent use with calcium channel blockers may lead to marked orthostatic hypotension.
Potentially Fatal: Significant hypotension may occur when used with phosphodiesterase-5 inhibitors.
Severe hypotension or anaemia, hypovolaemia, heart failure due to obstruction, or raised intracranial pressure due to head trauma or cerebral haemorrhage.
Common
- Headache
- Dizziness
- Increased heart rate
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
Hypotension, tachycardia, flushing, headache, dizziness, palpitation, syncope, confusion. Nausea, vomiting, abdominal pain. Restlessness, weakness and vertigo. Dry mouth, chest pain, back pain, oedema, fatigue, abdominal pain, constipation, diarrhoea, dyspepsia and flatulence.
Potentially Fatal: Severe hypotension and cardiac failure.
There are no adequate and controlled studies to date with Isosorbide-5-mononitrate in pregnant women, and the drug should be used during pregnancy only when the potential benefit justified possible risks to the fetus. Execration of Isosorbide-5-mononitrate into human milk is unknown, so precaution should be taken when it is administered to a nursing mother.
Precaution:
Severe renal or severe hepatic impairment, hypothyroidism, malnutrition, or hypothermia. Caution in patients who are already hypotensive. May aggravate angina caused by hypertrophic cardiomyopathy. Tolerance may develop after long-term treatment. Lactation.
Lactation: Unknown whether drug crosses into breast milk; use caution
Symptoms: Most common symptoms are hypotension, throbbing headache, tachycardia, and flushing. Methemoglobinemia may occur with massive doses.Treatment: Treatment consists of placing patients in recumbent position and administering fluids; alpha-adrenergic vasopressors may be required. Methemoglobinemia should be treated with methyline blue at a dose of 1-2 mg/kg IV slowly.
Store at 20°-30°C.
Nitrates: Coronary vasodilators
Isosorbide mononitrate relaxes vascular smooth muscles by stimulating cyclic-GMP. It decreases left ventricular pressure (preload) and arterial resistance (afterload).
Pregnancy Category B: Reproduction studies performed in rats and rabbits at doses of up to 540 and 810 mg/kg/day, respectively, have revealed no evidence of harm to the fetus due to isosorbide mononitrate. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, Isosorbide Mononitrate should be used during pregnancy only if clearly needed.Nursing Mothers: It is not known whether isosorbide mononitrate is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when isosorbide mononitrate is administered to a nursing woman.
Samm Care