Uses of Meczin: - Motion sickness - Vertigo Motion sickness, Vertigo and Vestibular disorders Meczin and Pyridoxine Hydrochloride is contraindicated in patients who are hypersensitive to these ingredients.

Anti-emetic drugs

Meclizine has antiemetic, anticholinergic and antihistaminic properties. It reduces the sensitivity of the labyrinthine apparatus. The action may be mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), peripheral nerve pathways, the VC, or other CNS centers. Meclizine has an onset of action of 30 to 60 minutes, depending on dosage; their duration of action is 12 to 24 hours.

How to use Meclizine Hydrochloride: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Meclizine Hydrochloride may be taken with or without food, but it is better to take it at a fixed time. Administration: May be taken with or without food. Adult Dose: Oral Motion sickness Adult: 25-50 mg 1 hr before travelling and repeat 24 hrly if needed. Vertigo and vestibular disorders Adult: 25-100 mg daily in divided doses. Discontinue if there is no response after 1-2 wk of treatment. Nausea and vomiting 25-50 mg daily Radiation sickness: 50 mg administered 2-12 hours prior to radiation treatment. Prevention of nausea and vomiting associated with emergency contraceptive pill (ECP) : 25-50 mg, 1 hour before first ECP dose; repeat if needed in 24 hours. Child Dose: Oral <12 years: Safety and efficacy not established Motion Sickness >12 years: 12.5-50 mg PO given 1 hour before travel and then daily PRN Vertigo >12 years: 25-100 mg/day PO in single daily dose or divided q6-12hr

Additive effects with CNS depressants, neuroleptics, anticholinergics, alcohol.

Meclizine Hydrochloride and Pyridoxine Hydrochloride is contraindicated in patients who are hypersensitive to these ingredients.

Common - Sleepiness Headache, drowsiness, vomiting, dry mouth, fatigue. Rarely, blurred vision.

Meclizine shows no risk of birth defects or abnormalities when administered during pregnancy. Although Meclizine may excrete into the milk, it causes no harm in nursing babies.

Precaution: Patients should be warned that Meclizine Hydrochloride may impair their ability to perform hazardous activities requiring mental alertness or physical coordination (e.g., operating machinery, driving a motor vehicle). Patients should avoid alcoholic beverages while taking this drug. Due to its potential anticholinergic action, this drug should be used with caution in patients with asthma, glaucoma or enlargement of the prostate gland. Lactation: Not known if excreted in milk; use caution

Symptoms: Extreme excitability, seizures, drowsiness and hallucinations. Treatment: Appropriate supportive and symptomatic treatment. Consider dialysis.

Store in a cool & dry place and away from children.

Anti-emetic drugs

Meclozine blocks vasopressor response to histamine and has a slight blocking action against acetylcholine. It decreases excitability of the middle ear labyrinth and blocks conduction in the middle ear vestibular-cerebellar pathways.

Meclizine shows no risk of birth defects or abnormalities when administered during pregnancy. Although Meclizine may excrete into the milk, it causes no harm in nursing babies.