Lomir 2.5 mg
Isradipine
Category: Tablet
Manufacturer: Novartis (Bangladesh) Ltd.
Price: 543.02 ৳
28's pack
piece
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Related Medicines
Hypertension
Cardiogenic shock; recent MI or acute unstable angina; severe aortic stenosis; lactation; porphyria.
Calcium-channel blockers
Isradipine is a dihydropyridine Calcium channel blocker. It prevents Ca++ ions from entering the slow channels or select voltage-sensitive areas of vascular smooth muscle and myocardium during depolarisation, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation.
Administration:
May be taken with or without food.
Adult Dose:
Oral
Hypertension
Adult: Initially, 2.5 mg bid, increase if necessary after 3-4 wk to 5 mg bid, or 10 mg bid as required.
Elderly: Initially, 1.25 mg bid. Maintenance: 2.5 or 5 mg once daily.
Hepatic impairment: Initially 1.25 mg bid. Maintenance: 2.5 or 5 mg once daily.
Concurrent admin w/ enzyme-inducing drugs (e.g. rifampicin, phenobarbital, carbamazepine) reduced plasma concentrations of isradipine. Increased bioavailability w/ cimetidine. May increase serum levels w/ CYP3A4 inhibitors (e.g. macrolides, HIV protease inhibitors, azole antifungals, delavirdine).
Cardiogenic shock; recent MI or acute unstable angina; severe aortic stenosis; lactation; porphyria.
>10%
Headache (2-22%)
1-10%
Edema (1-9%),Dizziness (2-8%),Palpitation (1-5%),Flushing (1-5%),Tachycardia (1-3%),Chest pain (2-3%),Rash (2%),Nausea (1-5%),Vomiting (<1%),Diarrhea (≤ 3%),Weakness (<1%),Dyspnea (1-3%),Urinary frequency (1-3%)
<1%
Drug-induced gingival hyperplasia,Angioedema,Drowsiness,Hyperhidrosis,Leg pain,Nasal congestion.Drug fever,Dysuria.Impotence,Pruritus,Urticaria,Weight gain,Myocardial infarction
Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus
Precaution:
Hypotension, poor cardiac reserve, heart failure. Pregnancy.
Lactation: not known if excreted into breast milk
Symptoms: Excessive peripheral vasodilation with subsequent marked and prolonged systemic hypotension and tachycardia. Management: Symptomatic and supportive treatment. Emesis, gastric lavage, admin of activated charcoal followed in 30 min by a saline cathartic. A vasoconstrictor (e.g. epinephrine) may be useful in restoring normotensive state. Refractory hypotension or AV conduction disturbances may be treated with IV Ca salts or glucagon.
Store below 30° C.
Calcium-channel blockers
Isradipine is a dihydropyridine Ca channel blocker. It prevents Ca ions from entering the slow channels or select voltage-sensitive areas of vascular smooth muscle and myocardium during depolarisation, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation.
Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus
Samm Care