Uses of Lindiol Tablet: - Contraception Contraception Pregnancy, Cardiovascular diseases, Thromboembolic disorders, Severe hypertension, Severe liver disease, Known or suspected estrogen dependent tumor, Endometrial hyperplasia

Oral Contraceptive preparations

Estradiol is the major oestrogen in pre-menopausal women. Ethinylestradiol has similar actions as oestradiol. It is responsible for the development and maintenance of female reproductive system and secondary sexual characteristics. It also inhibits anterior pituitary by negative feedback effect and causes capillary dilation, fluid retention and protein anabolism.Lynestrenol is a progestogen structurally related to norethisterone. It may be used alone or as the progestogenic component of some oral contraceptives.

How to use Ethinylestradiol + Lynestrenol: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ethinylestradiol + Lynestrenol may be taken with or without food, but it is better to take it at a fixed time. Administration: Should take the pills at about the same time every day, preferably after the evening meal or at bedtime. Each subsequent pack is started on the day after the current pack is completed.Continue taking one pill each day.It is most likely that your menstruation will start while taking the brown pills. Do not discontinue taking the brown pills. When pt wish period to begin, just stop tablet taking. While using the second pack woman may have some breakthrough bleeding or spotting. Start with your next pack after the usual 7 day red inactive pill interval. The woman must take the extra active pill(s) needed from a back up pack after vomiting. Adult Dose: Contraception 1 active tablet PO daily for 21 days, then 1 brown iron tablet PO daily for 7 days Start with next pack after the usual 7 day brown inactive pill interval.

CYP1A2 and CYP3A4 inducers such as aminoglutethimide, carbamazepine, phenobarbital, and rifampin may decrease the effects of estradiol. May enhance the effects of hydrocortisone and prednisolone when used together. Altered anticoagulant effect when used with dicoumarol. Potentially Fatal: Antibiotics (ampicillin, tetracycline, sulphonamides and chloramphenicol) can cause intermenstrual bleeding or failure of contraception. Reduced efficacy of antihypertensives or hypoglycaemic drugs. Increased metabolism and subsequent reduction in efficacy with enzyme-inducing agents e.g. carbamazepine, griseofulvin, phenobarbital, phenytoin and rifampicin. Adjustment in antidiabetic dose may be required. May increase plasma levels and toxicity of ciclosporin.

Pregnancy, Cardiovascular diseases, Thromboembolic disorders, Severe hypertension, Severe liver disease, Known or suspected estrogen dependent tumor, Endometrial hyperplasia

Common - Nausea - Headache - Breast pain - Irregular uterine bleeding Nausea, vomiting, Cholestatic jaundice, Thrombosis, BP rise, Rash, Headache, migraine, mood change, Breast tenderness, pain, enlargement, secretion

Pregnancy Category X. Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

Precaution: Some medications may interfere with the efficacy of the pill. Contact your doctor if you are taking any drugs, such as antibiotics, rifampicin or medicines for seizures. You may have to use another method of contraception during this time.

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Estradiol is the major oestrogen in pre-menopausal women. Ethinylestradiol has similar actions as oestradiol. It is responsible for the development and maintenance of female reproductive system and secondary sexual characteristics. It also inhibits anterior pituitary by negative feedback effect and causes capillary dilation, fluid retention and protein anabolism. Lynestrenol is a progestogen structurally related to norethisterone. It may be used alone or as the progestogenic component of some oral contraceptives.