Uses of Lerzin: - Allergic conditions Allergic rhinitis, Hay fever, Allergies, Urticaria Hypersensitivity; lactation.

How to use Cetirizine Dihydrochloride: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cetirizine Dihydrochloride may be taken with or without food, but it is better to take it at a fixed time. Administration: May be taken with or without food. Adult Dose: Oral Allergic conditions Adult: 10 mg once daily or 5 mg bid. Elderly: Initially, 5 mg once daily. Hepatic impairment: Initially, 5 mg once daily. Syrup: Adults: 2 teaspoon once daily or 1 teaspoon twice daily. Child Dose: Oral Allergic conditions Child: 6-23 mth 2.5 mg once daily increased to max of 2.5 mg bid in childn >12 mth; 2-5 yr 5 mg once daily or in 2 divided doses; >6 yr 10 mg once daily or in 2 divided doses. Syrup: Children over 6 years: 2 teaspoon once daily or 1 teaspoon twice daily. Children 2-6 years: 1 teaspoonful once daily or 1/2 teaspoon twice daily. <2 years: Safety and efficacy not established Renal Dose: Renal impairment GFR >50 mL/min: Dose adjustment not necessary GFR ? 50 mL/min: 5 mg PO qDay Peritoneal dialysis: 5 mg PO qDay Intermittent hemodialysis: 5 mg PO qDay; may also administer 3 times weekly

Additive CNS depression when administered concomitantly w/ other CNS depressants (e.g. sedatives, tranquilisers).

Hypersensitivity; lactation.

Common - Sleepiness >10% Somnolence (2-14%),Headache (11-14%) 1-10% Fatigue (5.9%),Dry mouth (5%),Dizziness (2%),Diarrhea (2-3%),Malaise (4%),Bronchospasm (2-3%),Vomiting (2-3%),Epistaxis (2-4%) <1% Stomach pain,Drowsiness,Angioedema,Fussiness,Hallucinations,Hypotension,Tremor,Tongue discoloration

Precaution: Hepatic or renal impairment; elderly; tasks requiring mental alertness eg, driving or operating heavy machinery; pregnancy. Lactation: Excreted in breast milk; use not recommended

Cetirizine is a potent and highly selective antagonist of the peripheral histamine H1-receptor on effector cells in the GI tract, blood vessels and resp tract.

Pregnancy There are no adequate and well-controlled studies in pregnant women Lactation Cetirizine has been reported to be present in human breast milk In mice and beagle dogs, studies indicated that cetirizine was excreted in milk When a drug is present in animal milk, it is likely it will be present in human milk