Uses of Ketron: - Pain relief Pain, Dysmenorrhea, Rheumatic disorders Ketron tablets are not recommended to use in patients who are: - Allergic to this product or any of its components, aspirin or other non-steroidal anti-inflammatory medicines. - Have suffered attacks of asthma, bronchospasm, acute rhinitis, nasal polyps, urticaria, angioedema (swollen face, eyes, lips, or tongue, or difficulty in breathing), after taking aspirin or other non-steroidal anti-inflammatory medicines. - Have or have previously suffered from a peptic ulcer or chronic gastro-intestinal disorders. - Have had previously gastro-intestinal haemorrhage (bleeding). - Have suffered from bronchial asthma. - Have severe heart failure, moderate to severe renal dysfunction or severely impaired hepatic function. - Have a bleeding disorder, a blood clotting disorder or taking an anticoagulant. - Pregnant or breast-feeding.

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Description: Dexketoprofen is an isomer of ketoprofen. It is a propionic acid derivative with analgesic, anti-inflammatory and antipyretic properties. It is a non-steroidal anti-inflammatory drug (NSAID) that reduces prostaglandin synthesis via inhibition of cyclooxygenase pathway (both COX-1 and COX-2) activity.Onset: About 30 min.Duration: About 4-6 hr.

How to use Dexketoprofen: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Dexketoprofen is to be taken empty stomach. Administration: Should be taken on an empty stomach. Take 30 min before meals, esp for quick relief of acute pain. Adult Dose: Adult: PO Rheumatic disorders 100-200 mg/day in 2-4 divided doses. Max: 300 mg/day in divided doses. Pain and inflammation 25-50 mg 6-8 hrly. Max: 300 mg/day. Elderly: Initial total daily dose should not exceed 50 mg/day. May increase to the doses recommended for general population only if well tolerated. Hepatic Impairment: Mild to moderate impairment: Reduce initial dose to 50 mg/day. Not to be used in severe hepatic impairment. Renal Dose: Mild renal impairment: Reduce initial dose to 50 mg/day. Not to be used in moderate to severe renal impairment.

Increased risk of GI ulcers & bleeding (synergistic effect) w/ other NSAIDs. Increased risk of haemorrhagic effect of oral anticoagulants. Increased risk of haemorrhage w/ heparin. Increased blood lithium levels, which may reach toxic values, w/ lithium. Increased haematological toxicity of methotrexate at high dose of ?15 mg/wk. Increased toxic effects of hydantoins & sulphonamides. Increase risk of bleeding & damage of GI mucosal w/ anticoagulant. Increase hypoglycemic effect of sulfonylurea agents.

Dexketoprofen tablets are not recommended to use in patients who are: - Allergic to this product or any of its components, aspirin or other non-steroidal anti-inflammatory medicines. - Have suffered attacks of asthma, bronchospasm, acute rhinitis, nasal polyps, urticaria, angioedema (swollen face, eyes, lips, or tongue, or difficulty in breathing), after taking aspirin or other non-steroidal anti-inflammatory medicines. - Have or have previously suffered from a peptic ulcer or chronic gastro-intestinal disorders. - Have had previously gastro-intestinal haemorrhage (bleeding). - Have suffered from bronchial asthma. - Have severe heart failure, moderate to severe renal dysfunction or severely impaired hepatic function. - Have a bleeding disorder, a blood clotting disorder or taking an anticoagulant. - Pregnant or breast-feeding.

Common - Vomiting - Nausea - Stomach pain - Indigestion - Heartburn As with all medicines, Dexketoprofen may cause some unwanted effects in some patients. These are described below and are characteristic of non steroidal anti-inflammatory drugs: - Common (1 - 10%): nausea, vomiting, diarrhoea, stomach pain or heartburn. - Uncommon (0.1 - 1%): sleep disorders, nervousness, headache, dizziness,vertigo, palpitations, constipation, dry mouth, flatulence, skin rash, fatigue, hot flushes, shivering, general malaise. - Rare (0.01-0.1%): stomach ulceration, gastric haemorrhage or perforation, pins and needles, high blood pressure, water retention, slowed breathing rate, increased hepatic enzymes, increased sweating. - Very rare / isolated cases (<0.01%): blurred vision, ringing in the ear, low blood pressure, haematological reactions, hepatic or renal damage, dermatological and photosensitivity reactions, bronchospasm or anaphylaxis. - In patients with systemic lupus erythematosus or mixed connective tissue disease, anti-inflammatory medicines may rarely cause isolated cases of fever, headache and rigidity of the nape (back of the neck).

The use of Dexketoprofen tablets during pregnancy or breast-feeding is not recommended

Precaution: The medicine should be used with caution in conditions mentioned below: - Allergic to any other medicines. - Kidney disease, liver disease, heart disease or fluid retention conditions. - Blood disorder, systemic lupus erythematosus or mixed connective tissue disease.

Administer activated charcoal if more than 5 mg/kg has been ingested by an adult or a child within an hr. Symptomatic therapy should be provided. Dexketoprofen is dialysable.

Store at a cool & dry place protected from light and moisture. Keep out of reach of children.

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Dexketoprofen exhibits anti-inflammatory, analgesic and antipyretic properties. It potently inhibits the enzyme cyclooxygenase resulting in prostaglandin synthesis inhibition.

The use of Dexketoprofen tablets during pregnancy or breast-feeding is not recommended.