Uses of Juveprox: - Fever - Headache - Arthralgia (joint pain) - Muscle pain - Dental pain - Post operative pain - Pain during menstruation - Osteoarthritis - Rheumatoid arthritis - Ankylosing spondylitis - Gout Rheumatoid arthritis, Osteoarthritis, Juvenile rheumatoid arthritis Previous or active peptic ulceration, known hypersensitivity to NSAIDs. Perioperative pain in CABG setting.

How to use Oxaprozin: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Oxaprozin may be taken with or without food, but it is better to take it at a fixed time. Avoid Oxaprozin with herbs/food with anti-platelet activity such as alfalfa, anise, bilberry, grape seed, green tea, turmeric, fenugreek, garlic, ginger. Administration: Take with food or water to avoid GI effects Adult Dose: Osteoarthritis Initial in mild to moderate disease: 600mg PO qDay Usual in moderate to severe disease: 1200mg PO qDay Maximum 1,800 mg/day or 26 mg/kg/day, whichever is lower, divided PO q12hr Rheumatoid Arthritis 1200mg PO qDay (individualize) Maximum 1,800 mg/day or 26 mg/kg/day, whichever is lower, divided PO q12hr Hepatic Impairment Caution in patients with severe liver impairment Child Dose: Juvenile Rheumatoid Arthritis <6 years Safety and efficacy not established >6 years 22-31 kg: 600 mg PO qDay 32-54 kg: 900 mg PO qDay >55 kg: 1200 mg PO qDay Renal Dose: Renal Impairment Severe renal impairment or on dialysis: 600 mg PO qDay; may increase to 1200 mg/day; monitor closely

Increased risk of salicylate toxicity with aspirin. May increase effects of oral anticoagulants. May reduce effects of beta-blockers, diuretics and other antihypertensive agents. May increase risk of methotrexate and lithium toxicity.

Previous or active peptic ulceration, known hypersensitivity to NSAIDs. Perioperative pain in CABG setting.

Common - Vomiting - Nausea - Indigestion Common Edema,Rash,Abdominal pain,Anorexia,Constipation,Diarrhea,Indigestion,Nausea/Vomiting,GI ulcer,Gross bleeding with perforation,Heartburn,Anemia,LFT's increased.Tinnitus,Dysuria, Increased frequency of urination,Myocardial infarction (<2%) <1% Hypertension (<1%),Palpitations (<1%),Thrombotic tendency observations,Erythema multiforme (rare),Scaling eczema,Stevens-Johnson syndrome (rare),Toxic epidermal necrolysis (rare),Cerebrovascular accident,Gastrointestinal hemorrhage (<1%),Agranulocytosis (rare),Leukopenia (<1%),Thrombocytopenia (<1%),Hepatitis (rare),Jaundice, Liver failure,Anaphylactoid reaction (<1%),Amblyopia (<1%),Hearing loss (<1%),Acute renal failure (rare),Hematuria (rare),Interstitial nephritis (rare),Bronchospasm,Serum sickness due to drug (rare) Potentially Fatal: Anaphylactoid reactions, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, severe hepatic reactions.

Precaution: Be alert for ulceration and bleeding in patients treated chronically. History of serious GI events, alcoholism, smoking, other factors known to be associated with peptic ulcer. Elderly or debilitated patients. Uncompensated cardiac failure, history of hypertension, cardiac decompensation, chronic diuretic therapy, conditions predisposing to fluid retention. Renal and hepatic impairment. Underlying coagulation defects or patients who are undergoing surgical procedures where a high degree of haemostasis is required. Pregnancy (avoid in 3rd trimester) and lactation. Lactation: not known whether excreted in breast milk; effect on infant unknown

Symptoms: Acute renal failure, vomiting, drowsiness, leukocytosis. Management: Supportive and symptomatic. Multiple admin of charcoal may be required to reduce potential for delayed toxicities.

Store at 25° C. Protect from light.

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Oxaprozin is a propionic acid derivative NSAID. It inhibits the enzyme cyclooxygenase resulting in the blockage of prostaglandin synthesis.

Pregnancy Category: C; D in 3rd trimester or near delivery.