Uses of Iopaque: - Diagnostic agent Radiographic contrast medium for diagnostic procedures Procedure-specific. Intrathecal: Myelography in significant local or systemic infection where bacteremia is likely; concurrent use with corticosteroids; repeat myelography in the event of technical failure (risk of overdosage). Hysterosalpingography: During menstrual period or when menstrual flow in imminent; presence of infection; pregnancy, 6 mth after termination of pregnancy or 30 days after conization or curettage.

How to use Iohexol: Your doctor or nurse will give you this medicine. Kindly do not self-administer. Adult Dose: Intravascular Angiocardiography: ventriculography, pulmonary arteriography, venography & studies of collaterol arteries Ventriculography: 40 mL, range of 30-60 mL; may be repeated as needed, not to exceed 250 mL Selective Coronary Arteriography: 5 mL. range 3-14 mL per injection Aortic Root and Arch Study: 50 mL, range 20-75 mL, when used alone Pulmonary Angiography: 1 mL/kg Combined Angiographic Procedures: Multiple Procedures not to exceed 5 mL/kg or 250 mL Aortography and Selective Arteriography - Aorta: 50-80 mL - Major branches incl celiac, mesenteric arteries: 30-60 mL - Renal arteries: 5-15 mL; not to exceed 250 mL/Iohexol 350 when repeat injection indicated Cerebral Arteriography: Common Carotid Artery: 6-12 mL Internal Carotid Artery: 8-10 mL External Carotid Artery: 6-9 mL Vertebral Artery: 6-10 mL CT Scanning of the Body Head Imaging via injection: 70-150 mL (Iohexol 300); 80 mL (Iohexol 350) Body Imaging via injection: 50-200 mL (Iohexol 300); 60-100 mL (Iohexol 350) Digital Subtraction Iohexol 350 Usual amount used for IV digital technique is 30-50 mL Administer as bolus at 7.5-30 mL/sec using pressure injector Excretory Urography Iohexol 300/350: 200-350 mgI/kg body weight Hysterosalpingography Iohexol 300: 15-20 mL, but varies with anatomy and/or disease state Child Dose: Intravascular Iohexol 300/350 Angiocardiography: ventriculography, pulmonary arteriography, venography & studies of collaterol arteries Ventriculography: Iohexol 350: 1.25 mL/kg, range 1-1.5 mL/kg; not to exceed 5 mL/kg or 250 mL, when multiple injections given Iohexol 300: 1.75 mL/kg, range 1.5-2 mL/kg; not to exceed 6 mL/kg or 291 mL, when multiple injections given Pulmonary Angiography: 1 mL/kg Combined Angiographic Procedures - Multiple Procedures -Iohexol 350: Not to exceed 5 mL/kg or 250 mL -Iohexol 300: Not to exceed 6 mL/kg or 291 mL Aortography and selective arteriography: 1 mL/kg single inj dose; not to exceed 5 mL/kg or 250 mL CT Scanning of the Body Head imaging: 1-2 mL/kg; not to exceed 35 gI Iohexol 300 Body imaging via injection: 50-200 mL (Iohexol 300); 60-100 mL (Iohexol 350) Excretory Urography Iohexol 300: 0.5-3 mL/kg of body weight Infants/children: According to age and body weight Usual dose: 1-1.5 mL/kg; not to exceed 3 mL/kg

Procedure-specific. Intrathecal: Myelography in significant local or systemic infection where bacteremia is likely; concurrent use with corticosteroids; repeat myelography in the event of technical failure (risk of overdosage). Hysterosalpingography: During menstrual period or when menstrual flow in imminent; presence of infection; pregnancy, 6 mth after termination of pregnancy or 30 days after conization or curettage.

Common - Nausea - Vomiting - Diarrhea Flushing or a sensation of heat; pain, extravasation, thrombophlebitis at the inj site; nausea, vomiting, headache, and dizziness; urticaria, pruritus, pallor, sweating, metallic taste, weakness, coughing, rhinitis, sneezing, lachrymation, visual disturbances; hypotension, tachycardia, bradycardia, transient ECG abnormalities, haemodynamic disturbances; dyspnoea, bronchospasm, angioedema, severe urticaria; convulsions, paraesthesia, paralysis; acute renal failure; thromboembolism, disseminated intravascular coagulation, thrombocytopenia; hyperthyroidism, thyroid storm thyrotoxicosis. Potentially Fatal: Profound hypotension, pulmonary oedema, respiratory arrest, ventricular fibrillation, circulatory failure, cardiac arrest, coma.

Precaution: Asthma or a history of allergies (risk of anaphylactoid reactions is increased); compromised blood-brain barrier (severe neurotoxicity after intrathecal use); epilepsy and brain tumour (higher risk of convulsions); severe hepatic or renal impairment, diabetics with renal impairment, dehydration and others who may be at increased risk of renal failure; multiple myeloma (dehydration from use may cause precipitation of protein in the renal tubules, leading to anuria and fatal renal failure); severe hypertension; advanced cardiac disease; phaeochromocytoma; sickle-cell disease; hyperthyroidism; debilitated, severely ill, very old, or very young patients; occlusive vascular disease. Special care to ensure that 140 and 350 mg iodine/ml solutions are not given intrathecally. Adequate resuscitative facilities should be available when radiographic procedures are undertaken, and patients should be kept under observation for a suitable period after the procedure. Lactation: Not known; not recommended

Allows for radiographic visualization through the opacification of vessels and anatomical structures in the path of flow of the contrast media.