Uses of Fenazine: - Schizophrenia In the long-term management of psychotic disorders including, Schizophrenia, Mania, Organic brain syndrome Fenazine oily Injection is contraindicated in patients with hypersensitivity to the drug. Also contraindicated in comatose or severely depressed states, blood dyscrasias, liver disease, pregnancy (3rd trimester), lactation.

Phenothiazine drugs

Fluphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.

How to use Fluphenazine Decanoate: Your doctor or nurse will give you this medicine. Kindly do not self administer. Adult Dose: Intramuscular Psychoses; Mania; Schizophrenia Adult: As decanoate: Initially, 12.5 mg adjusted according to response. Maintenance: 12.5-100 mg at intervals of 2-6 wk. For doses >50 mg, increments should be made slowly in steps of 12.5 mg. Elderly: 6.25 mg adjusted according to response. Hepatic impairment: Use with caution; monitor Child Dose: Safety and efficacy not established Renal Dose: Renal impairment: Use with caution; monitor

Reduces antihypertensive effects of guanethidine, methyldopa and clonidine. Lithium toxicity. Reduced bioavailability with antacids. Increased risk of arrhythmia when used with drugs that prolong QT interval. May cause electrolyte disturbance when used with diuretics. Potentially Fatal: Additive CNS depressant effects with alcohol, barbiturates, hypnotics, sedatives, opiates and antihistamines.

Fluphenazine Decanoate oily Injection is contraindicated in patients with hypersensitivity to the drug. Also contraindicated in comatose or severely depressed states, blood dyscrasias, liver disease, pregnancy (3rd trimester), lactation.

Common - Abnormality of voluntary movements - Constipation - Dryness in mouth - Increased prolactin level in blood - Injection site reactions (pain, swelling, redness) - Muscle stiffness - Orthostatic hypotension (sudden lowering of blood pressure on standing) - Sleepiness - Tremor - Urinary retention - Weight gain Frequency Not Defined Confusion,Decreased gag reflex Extrapyramidal symptoms Akathisia,Dystonia,Dyskinesia,Muscle stiffness,Neuroleptic malignant syndrome (NMS; infrequent but serious),Parkinsonism,Tardive dyskinesia Common Anticholinergic effects,Sedation,Weight gain,Erectile dysfunction,Oligomenorrhea or amenorrhea, Less common Orthostatic hypotension (after IM injection), tachycardia,Agitation, anxiety, cerebral edema, depression, dizziness, euphoria, headache, poikilothermia, restlessness, weakness,Anorexia, constipation, dyspepsia, ileus,Lens opacities (with prolonged use) Uncommon ECG changes,Photosensitivity,Pruritus,Diarrhea,Blood dyscrasia,Galactorrhea,Ejaculatory disorder Rare Seizure,Priapism,Cholestatic jaundice

The safety for the use of Fluphenazine decanoate during pregnancy has not yet been established; therefore the possible hazards should be weighed against the potential benefits when administering this drug to pregnant patients.

Precaution: Special precaution should be practiced in presence of convulsive disorders; hepatic, renal, cerebrovascular, respiratory and cardiovascular diseases. Also precaution should be observed in case of phenochromocytoma; bone marrow suppression; elderly or debilitated patients. Lactation: Drug enters breast milk; not recommended

Store at 15-30°C.

Phenothiazine drugs

Fluphenazine blocks postsynaptic dopamine D1 and D2 receptors in the mesolimbic system and decreases the release of hypothalamic and hypophyseal hormones. It reduces aggressiveness with disappearance of hallucinations and delusions.

The safety for the use of Fluphenazine decanoate during pregnancy has not yet been established; therefore the possible hazards should be weighed against the potential benefits when administering this drug to pregnant patients.