Adult Dose
Inhalation/Respiratory
Indicated in the regular treatment of asthma, where use of a combination (LABA + Inhaled Corticosteroid) has been found to be appropriate.
Adult:
Initial: 2 puffs of 100 mcg/5 mcg inhaled twice daily; may increase to higher dose after 2 wks if inadequate response.
Severe asthma (initial) or inadequate response to lower dose (after 2 wk):
2 puffs of 200 mcg/5 mcg inhaled twice daily.
Maximum daily dose: 800 mcg/20 mcg daily
Child Dose
Child: >12 yr
Initial: 2 puffs of 100 mcg/5 mcg inhaled twice daily; may increase to higher dose after 2 wks if inadequate response.
Severe asthma (initial) or inadequate response to lower dose (after 2 wk):
2 puffs of 200 mcg/5 mcg inhaled twice daily.
Maximum daily dose: 800 mcg/20 mcg daily
Hypersensitivity
Primary treatment for acute bronchospasm, status asthmaticus, or exercise-induced bronchospasm
Side effects of Mometasone + Formoterol inhaler :
1-10%
Nasopharyngitis (4.7%)
Headache (2-4.5%)
Sinusitis (2-3.3%)
<1%
Oral candidiasis
Pregnancy: There are no randomized clinical studies in pregnant women; there are clinical considerations with use in pregnant women In women with poorly or moderately controlled asthma, there is increased risk of several perinatal adverse outcomes such as preeclampsia in the mother and prematurity, low birth weight, and small for gestational age in the neonate; pregnant women with asthma should be closely monitored and medication adjusted as necessary to maintain optimal asthma control
Lactation: There are no available data on the presence of mometasone furoate, or formoterol fumarate in human milk; the effects on the breastfed child, or the effects on milk production; The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for therapy and any potential adverse effects on the breastfed infant from the drug or from the underlying maternal condition
Patient w/ severe asthma, risk factors for decreased BMD, CV disease (e.g. arrhythmia, coronary insufficiency, HTN, recent MI), DM, GI disease (e.g. diverticulitis, peptic ulcer, ulcerative colitis), myasthenia gravis, cataract/glaucoma, pheochromocytoma, seizure disorders, hypokalaemia, thyroid disease, bacterial (e.g. active or quiescent pulmonary TB), fungal, parasitic, and viral (e.g. chickenpox, measles, ocular herpes simplex) infections. Hepatic impairment. Childn. Pregnancy and lactation.
Mometasone: Glucocorticoid; elicits local anti-inflammatory effects on respiratory tract with minimal systemic absorption
Formoterol: Long-acting selective beta2-adrenergic agonist with rapid onset of action; acts locally as bronchodilator; stimulates intracellular adenyl cyclase, which results in increased cyclic adenosine monophosphate levels, causing relaxation of bronchial smooth muscle and inhibition of release of mast cell mediators
