Uses of Ilodon 2: - Schizophrenia - Mania Schizophrenia Hypersensitivity.

How to use Iloperidone: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Iloperidone may be taken with or without food, but it is better to take it at a fixed time. Adult Dose: Schizophrenia Day 1: 1 mg PO q12hr; increase qDay to effective dose of 6-12 mg PO q12hr Day 2: 2 mg PO q12hr, THEN increase qDay by 2 mg/day to effective dose of 6-12 mg PO q12hr; not to exceed 24 mg/day Must gradually increase dose to avoid orthostatic hypotension Hepatic impairment Mild: No dosage adjustment required Moderate: Caution advised Severe: Use not recommended Child Dose: Safety and efficacy not established Renal Dose: Renal impairment: Unlikely to have a significant impact since <1% of drug is excreted unchanged in urine

Hypersensitivity.

Common - Dizziness - Dryness in mouth - Fatigue - Nasal congestion (stuffy nose) - Orthostatic hypotension (sudden lowering of blood pressure on standing) - Sleepiness >10% Dizziness (20%), Dry mouth (15%), Nausea (10%), Somnolence (10%), Tachycardia (12%) 1-10% (selected) Diarrhea, Ejaculation failure, Myalgia, Nasal congestion, Orthostatic hypotension, Palpitations, Urinary incontinence, Weight gain Frequency Not Defined (selected) Priapism

Precaution: This drug is not approved for the treatment of patients with dementia-related psychosis. Prolongs QT interval; caution with other drugs/conditions that increase QTc. Not recommended in hepatic impairment. Risk of neuroleptic malignant syndrome and extrapyramidal symptoms. May cause anticholinergic side effects (eg., confusion, agitation). Blood dyscrasias (leukopenia, neutropenia, agranulocytosis) may occur. Orthostatic hypotension may occur. Lactation: not known if excreted in breast milk, do not nurse

May act by antagonizing a combination of dopamine type 2 (D2) and serotonin type 2 (5-HT2) receptors. Alpha blocker.