Hista 2 mg/5 ml
Chlorpheniramine Maleate
Category: Syrup
Manufacturer: Links Pharma
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Related Medicines
Uses of Hista:
- Allergic conditions
Urticaria, Sneezing, Watery eyes, Allergic conditions, Anaphylactic shock, Rhinitis, Itching
Hypersensitivity, Neonates.
Sedating Anti-histamine
Chlorpheniramine is an alkylamine antihistamine. It is one of the most potent H1 blocking agents and is generally effective in relatively low doses. Chlorpheniramine is not so prone to produce drowsiness, readily absorbed from the gastro-intestinal tract, metabolised in the liver and excreted usually mainly as metabolised in the urine.
How to use
Chlorpheniramine Maleate:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.
Chlorpheniramine Maleate may be taken with or without food, but it is better to take it at a fixed time.
Adult Dose:
Oral
Adult: 4 mg every 4-6 hr. Max: 24 mg daily.
Parenteral
Adjunct in the emergency treatment of anaphylactic shock
Adult: 10-20 mg IM, SC, or slow IV inj over 1 min. Max dose: 40 mg daily.
Child Dose:
Oral
Child: 1-2 yr: 1 mg bid,
2-5 yr: 1 mg every 4-6 hr,
6-12 yr: 2 mg every 4-6 hr.
Max: 6 mg daily (1-5 yr); 12 mg daily (6-12 yr).
Parenteral
Adjunct in the emergency treatment of anaphylactic shock
Child: 87.5 mcg/kg SC 4 times daily
Potentiates sedative effect of psychotropic drugs e.g. barbiturates, hypnotics, opioid analgesics, anxiolytics and antipsychotics. Interaction with alcohol could be dangerous (sedation/excitation).
Hypersensitivity, Neonates.
Common
- Dryness in mouth
- Sleepiness
- Drowsiness
- Loss of appetite
- Nausea
CNS depression, sedation, drowsiness, lassitude, dizziness. GI upsets, anorexia, or increased appetite, epigastric pain, blurring of vision, dysuria, dryness of mouth, tightness in chest, hypotension, muscular weakness, tinnitus, euphoria, headache, paradoxical CNS stimulation.
Potentially Fatal: CV collapse and respiratory failure.
Pregnancy Category B. Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Precaution:
Elderly, pylori duodenal obstruction, angle-closure glaucoma, urinary retention, prostatic hyperplasia, epilepsy, renal and hepatic impairment. May affect performance of skilled tasks. BPH, bladder neck obstruction, hypertension. Pregnancy, lactation.
CNS depression (including sedation, apnea, CV collapse), CNS stimulation (including insomnia, hallucination, tremors, convulsions), tinnitus, blurred vision, dizziness, ataxia, hypotension. Stimulation and atropine-like signs and symptoms (including dry mouth, fixed dilated pupils, flushing, hyperthermia, Gl symptoms) are more likely in children.
Store in a cool (Below 25°C temperature) and dry place protected from light. Keep out of the reach of children.
Sedating Anti-histamine
Chlorphenamine is an H1-receptor antagonist which competetively blocks H1-receptor sites on tissues.
Pregnancy
Antihistamine exposure in first trimester not reported to be associated with increased risk of malformations; animal studies not reported; there are no controlled data in human pregnancy; only recommended for use during pregnancy when benefit outweighs risk
Lactation
Excretion into human milk; the manufacturer recommends that caution be used when administering chlorpheniramine to nursing women; infants should be monitored for irritability or drowsiness; antihistamines may temporarily decrease maternal serum prolactin concentrations when administered prior to nursing infant for the first time
Samm Care