Anemia, Nutritional supplement, Folic acid deficiency, Megaloblastic anemia, Neural tube defect
This product is contraindicated in patients with a known hypersensitivity to any of the ingredients. Folic Acid is contraindicated in untreated cobalamine deficiency.
Drugs for Megaloblastic Anemia, Vitamin-B preparations
Folic acid is essential for the production of certain coenzymes in many metabolic systems such as purine and pyrimidine synthesis. It is also essential in the synthesis and maintenance of nucleoprotein in erythropoesis. It also promotes WBC and platelet production in folate-deficiency anaemia.
Administration:
May be taken with or without food.
Adult Dose:
Oral
Folate-deficient megaloblastic anaemia
Adult: 5 mg daily for 4 mth, up to 15 mg daily in malabsorption states. Continued dosing at 5 mg every 1-7 days may be needed in chronic haemolytic states, depending on the diet and rate of haemolysis.
Prophylaxis of megaloblastic anaemia in pregnancy
Adult: 0.2-0.5 mg daily.
Prophylaxis of neural tube defect in pregnancy
Adult: 4 or 5 mg daily starting before pregnancy and continued through the 1st trimester.
As supplement for women of child-bearing potential
Adult: 0.4 mg daily.
Child Dose:
Folic Acid Deficiency
Infants: 15 mcg/kg/day or 50 mcg/day
1-10 years: 1 mg/day initially, then 0.1-0.4 mg/day
Antiepileptics, oral contraceptives, anti-TB drugs, alcohol, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides may result to decrease in serum folate contrations. Decreases serum phenytoin concentrations.
This product is contraindicated in patients with a known hypersensitivity to any of the ingredients. Folic Acid is contraindicated in untreated cobalamine deficiency.
Pregnancy Category A. Adequate and well-controlled human studies have not shown any risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
Precaution:
Treatment resistance may occur in patients with depressed haematopoiesis, alcoholism, deficiencies of other vitamins. Neonates.
Lactation: Drug enters breast milk; safe for nursing
Store below 30°C in a dry place, away from light. Keep out of the reach of children.
Drugs for Megaloblastic Anemia, Vitamin-B preparations
Folic acid: Required for nucleoprotein synthesis and the maintenance of normal erythropoiesis; folic acid is converted in the liver and plasma to its metabolically active form, tetrahydrofolic acid, by dihydrofolate reductase; prevents neural tube defects in women of childbearing potential and higher doses required during pregnancy.
Pregnancy category: A
Lactation: Drug enters breast milk; safe for nursing
