Uses of Fluvas: - High cholesterol - Prevention of heart attack and stroke Hyperlipidaemias, Hypercholesterolemia Acute liver disease; unexplained persistently raised serum aminotransferase concentrations; porphyria; pregnancy; lactation.

Other Anti-anginal & Anti-ischaemic drugs, Statins

Fluvastatin acts by competitively inhibiting HMG-CoA reductase, the enzyme for cholesterol synthesis. It reduces total cholesterol, triglycerides, LDL and VLDL concentrations in plasma. It also increases HDL concentrations.

How to use Fluvastatin: Use it as advised by your doctor or check the label for directions before use. Fluvastatin may be taken with or without food, but it is better to take it at a fixed time. Administration: May be taken with or without food. Adult Dose: Oral Hypercholesterolemia & Mixed Dyslipidemia Adult: Initially, 20-40 mg once daily in the evening, may increase at intervals of 4 wk to max 80 mg/day in 12hrly divided dose. Hepatic Impairment Contraindicated in active liver disease or unexplained transaminase elevations Child Dose: Oral Hyperlipidaemias Child: Heterozygous familial hypercholesterolaemia: 10-16 yr 20 mg once daily. If necessary, may increase dose at 6-wkly intervals to 40 mg bid or 80 mg once daily as modified-release. Renal Dose: Renal Impairment CrCl <30 mL/min: Adjust dose amount; not to exceed 40 mg/day

Bleeding and increased prothrombin time w/ coumarin anticoagulants. May increase the risk of myopathy and rhabdomyolysis w/ HIV protease inhibitors, colchicine, bezafibrate, ciprofibrate or niacin (nicotinic acid), ciclosporin and fluconazole. Reduced bioavailability w/ concomitant rifampicin.

Acute liver disease; unexplained persistently raised serum aminotransferase concentrations; porphyria; pregnancy; lactation.

Common - Abdominal pain - Headache - Muscle pain - Weakness 1-10% Headache (9%),Dyspepsia (8%),Abdominal pain (5%),Diarrhea (5%),Myalgia (5%),Fatigue (3%),Insomnia (3%),Nausea (3%),Sinusitis (3%),Bronchitis (2%),UTI (2%),Transaminases increased (1.1%) <1% Rash,Back pain,Arthralgia,Myopathy,Rhabdomyolysis,Rupture of tendon,CPK increased,Pharyngitis,Rhinitis,Cough,Constipation,Pancreatitis,Dizziness

Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.

Precaution: History of liver disease; high alcohol intake. Manage hypothyroidism adequately before starting treatment. Report unexplained muscle pain. Monitor LFTs. Discontinue in case of marked or persistent increase in serum aminotransferase or creatine phosphokinase. Severe renal impairment. Lactation: enters breast milk; contraindicated

Management: Symptomatic and supportive treatment.

Store between 15-30° C.

Other Anti-anginal & Anti-ischaemic drugs, Statins

Fluvastatin acts by competitively inhibiting HMG-CoA reductase, the enzyme for cholesterol synthesis. It reduces total cholesterol, triglycerides, LDL and VLDL concentrations in plasma. It also increases HDL concentrations.

Pregnancy Category: X Lactation: enters breast milk; contraindicated