Epilim 200 mg/5 ml
Sodium Valproate
Category: Syrup
Manufacturer: Synovia Pharma PLC
Price: 80.54 ৳
100 ml bottle
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Sodium Vaiproate oral is indicated for the treatment of all types of epilepsy, e.g.
Partial seizures
Absence seizures (petit mal)
Generalized tonic-clonic seizures (grand mal)
Myoclonic seizures
Atonic seizures
Mixed seizures that include absence attack ... Read moreSodium Vaiproate oral is indicated for the treatment of all types of epilepsy, e.g.
Partial seizures
Absence seizures (petit mal)
Generalized tonic-clonic seizures (grand mal)
Myoclonic seizures
Atonic seizures
Mixed seizures that include absence attack
Prophylaxis of febrile convulsion
Prophylaxis of post-traumatic epilepsy.
It is also indicated in the treatment of bipolar disorder & prophylaxis of migraine.
Primary anti-epileptic drugs
Sodium Valproate shows antiepileptic properties in various types of seizures. The exact mechanism of Sodium Valproate is not yet established. However it is suggested that its activity is related to increased brain levels of Gama Amino Butyric Acid (GABA).
Adults:
Initial: 600 mg/ day in 2 divided doses, preferably after food. Dose may be increased by 200 mg/day at 3 days interval to a maximum of 2.5 gm daily in divided doses until control of seizure is achieved.
Maintenance dose:Usually 1-2 gm daily (20-30 mg/ kg daily).
Children (up to 20 kg):
Initial: 20 mg/kg daily in divided doses. Dose may be increased in severe cases with proper monitoring of plasma concentration.
Children (over 20 kg):
Initial: 400 mg/ day (irrespective of weight). Dose may be increased by 20-30 mg/ kg if required to achieve control.
Sodium Vaiproate appears to act as a non specific inhibitor of drug metabolism. Drugs to which it interacts most significantly are Phenobarbital, Phenytoin, Warfarin, Aspirin etc.
Sodium Valproate is contraindicated to patients who have known hypersensitivity to the drug and liver dysfunction. Use of Sodium Valproate is restricted during pregnancy and in women of childbearing potential.
The most common side effects are anorexia, nausea and vomiting. However, these side effects are minimized with the use of enteric coated tablets. Effects on the CNS include sedation, ataxia and tremor. These symptoms occur infrequently and usually respond to a decrease in doses. Rash, alopecia and stimulation of appetite have been observed occasionally. Sodium Vaiproate has several effects on hepatic function of which elevation of liver enzymes in plasma is observed in up to 40% of patients and often occurs asymptomatically during the first few months of therapy. Rarely a fulminate hepatitis that may be fatal may develop. Children below 2 years of age with other medical conditions and those being treated with multiple antiepileptic agents are specially prone to suffer from hepatic injury, acute pancreatitis and hyperammonemia have also been frequently associated with the use of Sodium Valproate.
Sodium Valproate crosses the placenta in humans which may lead to neural tube defects such as anencephaly and spina bifida if exposed in the first trimester. Sodium Valproate may excrete in breast milk. So treatment with Sodium Valproate may cause harm to new born baby.
Liver functions should be monitored before therapy and during first 6 months especially in patients most at risk, No undue potential for bleeding before starting and before major surgery must be ensured, Care should be taken in renal impairment, pregnancy, breast-feeding and systemic lupus erythematosus. Sodium Valproate is partially eliminated in the urine as a ketone metabolite, which may lead to a false interpretation of the urine ketone test. Sudden withdrawal of therapy should be avoided. Sodium Valproate should not be used during pregnancy and in women of childbearing potential.
Do not store above 30°C. Keep away from light and out of the reach of children.
Primary anti-epileptic drugs
Sodium Valproate, the active ingredient of this preparation is endowed with anti-epileptic activity against a variety of seizures. The mechanism by which Sodium Valproate exerts its anti-epileptic effects has not been established. However, it has been suggested that its activity is related to increase brain levels of gamma-aminobutyric acid (GABA).
Sodium Vaiproate crosses the placenta and in humans, exposure to valproate in the first trimester has been associated with neural tube defects such as anencephaly and spina bifida in newborn. Pregnant women treated with Sodium Vaiproate should be offered to estimate serum a-fetoprotein. Sodium Valproate is excreted in breast miik. However, breast-feeding by a mother taking Sodium Valproate probably causes no risk to the child.
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