Prevention and treatment of nausea, vomiting, dizziness, motion sickness, radiation sickness and vertigo associated with diseases of the vestibular system (e.g. Meniere's syndrome, labyrinthitis and other vestibular disturbances).
Anti-emetic drugs
Meclizine Hydrochloride prevents nausea and vomiting by reducing the activity of the center in the brain that controls nausea. It also prevents motion sickness by reducing excitability of neurons in the vestibular region of the brain. Pyridoxine Hydrochloride (vit. B6), either alone or combination has been used to prevent nausea and vomiting due to its antiemetic properties.
Nausea and vomiting during pregnancy: 1 tablet 1-2 times daily (after taking food) or as directed by the physician. Nausea and vomiting after surgery: 1-2 tablets daily.Nausea and vomiting induced by irradiation: 1 tablet (shortly before or after the irradiation). Motion sickness: 1-2 tablets one hour prior to journey. This dose may be repeated every 24 hours, if required.Vertigo associated with vestibular system diseases: 1 tablet 2 times daily or as required.
The CNS depressant effects of Meclizine can be potentiated by concurrent use of Ethanol or other CNS depressant agents such as Benzodiazepines, Barbiturates, Tricyclic antidepressants, opiate agonists, skeletal muscle relaxants and antihistamines. Concurrent use of other anticholinergics can potentiate the anticholinergic effects of Meclizine. Meclizine can increase the absorption of digoxin by decreasing gastrointestinal motility.
Meclizine Hydrochloride and Pyridoxine Hydrochloride is contraindicated in patients who are hypersensitive to these ingredients.
Drowsiness, dry mouth and, on rare occasions, blurred vision have been reported.
There is no evidence of adverse effects of this combination on pregnancy or on the health of the fetus or neonate. But account should be taken with the use of antihistamines to just before the parturition. Pyridoxine is considered as safe in pregnancy. Pyridoxine is excreted in human milk but meclizine is unknown whether it is excreted or not. So, this combination may be indicated during lactation, if clearly needed.
Patients should be warned that Meclizine Hydrochloride may impair their ability to perform hazardous activities requiring mental alertness or physical coordination (e.g., operating machinery, driving a motor vehicle). Patients should avoid alcoholic beverages while taking this drug. Due to its potential anticholinergic action, this drug should be used with caution in patients with asthma, glaucoma or enlargement of the prostate gland.
Symptoms: Extreme excitability, seizures, drowsiness and hallucinations.Treatment: Appropriate supportive and symptomatic treatment. Consider dialysis
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Anti-emetic drugs
Meclizine is a piperazine-derivative antihistamine that is used as an antiemetic. It has antiemetic, anticholinergic and antihistaminic properties. It reduces the sensitivity of the labyrinthine apparatus. The action may be mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), peripheral nerve pathways, the VC, or other CNS centers. Pyridoxine is vitamin B-6. It has been added to enhance the anti-emetic effects & as a dietary suppliment.
Pregnancy Category B. Large-scale human studies have not demonstrated adverse fetal effects. It has been suggested that based on available data, Meclizine presents the lowest risk of teratogenicity and is the drug of first choice in treating nausea and vomiting during pregnancy. Safety for use in the nursing mother has not been established.
