Efaxim 550 mg
Rifaximin
Category: Tablet
Manufacturer: Square Pharmaceuticals Ltd.
Price: 450.0 ৳
10's pack
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Related Medicines
Uses of Efaxim:
- Hepatic encephalopathy
Traveler's diarrhea, irritable bowel syndrome
Contraindicated in patients with a hypersensitivity to Rifaximin or to any of the rifamycin antimicrobial agents, or any components of this product.
4-Quinolone preparations
Rifaximin is a non-systemic, rifamycin antibiotic which is structural analog of rifampin. Rifaximin acts by binding to the beta-subunit of bacterial DNA-dependent RNA polymerase resulting in inhibition of bacterial RNA synthesis.
How to use
Rifaximin:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.
Rifaximin may be taken with or without food, but it is better to take it at a fixed time.
Administration:
May take with or without food
Adult Dose:
Traveler's Diarrhea
200 mg PO q8hr for 3 days
Hepatic Encephalopathy
Maintenance of remission
550 mg PO q12hr
Irritable Bowel Syndrome
Indicated for irritable bowel syndrome with diarrhea (IBS-D) in adult men and women
550 mg PO q8hr for 14 days; recurrence of symptoms can be retreated with a 14 day treatment course, up to 2 times
Child Dose:
Traveler's Diarrhea
<12 years: Safety and efficacy not established
>12 years: 200 mg PO q8hr for 3 days, with or without food
Although in vitro studies demonstrated the potential of rifaximin to interact with cytochrome P450 (CYP3A4), a clinical drug-drug interaction study demonstrated that rifaximin did not significantly affect the pharmacokinetics of midazolam. An additional clinical drug-drug interaction study showed no effect of rifaximin on the presystemic metabolism of an oral contraceptive containing ethinyl estradiol and norgestimate. Therefore, clinical interactions with drugs metabolized by human cytochrome P450 isozymes are not expected.
Contraindicated in patients with a hypersensitivity to Rifaximin or to any of the rifamycin antimicrobial agents, or any components of this product.
Common
- Vomiting
- Headache
- Dizziness
- Nausea
>10%
Flatulence (11%)
1-10%
Headache (10%),Rectal tenesmus (7%),Abdominal pain (7%),Defecation urgency (6%),Nausea (5%),Constipation (4%),Pyrexia (3%),Vomiting (2%)
Frequency Not Defined
Hypersensitivity reactions (including allergic dermatitis),Pruritus,Rash
Pregnancy Category C. There are no adequate and well controlled studies in pregnant women. Based on animal data, Rifaximin may cause fetal harm. It should be used during pregnancy only if the potential benefit outweighs the probable risk to the fetus. Discontinue nursing or drug, taking into account the importance of the drug to the mother.
Precaution:
Rifaximin is not found to be effective in patients with diarrhea complicated by fever and/or blood in the stools. Rifaximin therapy should be discontinued if diarrhea symptoms get worse or persist for more than 24-48 hours and an alternative antibiotic therapy should be considered. Pseudomembranous colitis has been reported with nearly all antibacterial agents and may range in severity from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents.
Lactation: Do not use if nursing or do not nurse
No specific information is available on the treatment of over dosage with Rifaximin. In case of over dosage, discontinue Rifaximin, treat symptomatically and institute supportive measures as required.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
4-Quinolone preparations
Antimicrobial action is a result of binding to the beta-subunit of bacterial DNA-dependent RNA polymerase, resulting in inhibition of transcription.
Hepatic encephalopathy: Inhibits growth of enteric ammonia-producing bacteria to indirectly reduce serum ammonia level.
Irritable bowel syndrome with diarrhea (off-label): Inhibits growth of enteric bacteria to reduce gas production.
Pregnancy category C. It is not known whether Rifaximin is excreted in human milk or not.
Samm Care