Uses of Didryl: - Motion sickness - Insomnia - Nasal allergy symptoms Allergic rhinitis, Allergic conditions, Motion sickness, Common cold, Insomnia, Extrapyramidal symptoms Hypersensitivity ; neonates, lactation.

Sedating Anti-histamine

Diphenhydramine is an antihistamine with anticholinergic and sedative effects. It competes with histamine for H1-receptor sites on effector cells in the GI tract, blood vessels and respiratory tract.

How to use Diphenhydramine Hydrochloride: Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Diphenhydramine Hydrochloride may be taken with or without food, but it is better to take it at a fixed time. Administration: May be taken with or without food. Adult Dose: Oral Allergic conditions; Treatment and prophylaxis of motion sickness Adult: 25-50 mg 3-4 times daily. For prevention of motion sickness, admin 30 min before exposure to motion. Max: 300 mg daily. Parkinson's disease Adult: Initially, 25 mg tid, may increase to 50 mg 4 times daily if necessary. Short-term management of insomnia Adult: 50 mg 30 min before bedtime as needed. Hepatic impairment: No dosage adjustment needed. Child Dose: Allergic Reaction 2-6 years: 6.25 mg q4-6hr; not to exceed 37.5 mg/day 6-12 years: 12.5-25 mg PO q4-6hr; not to exceed 150 mg/day >12 years: 25-50 mg PO q4-6hr; not to exceed 300 mg/day Occasional Insomnia >12 years: 50 mg PO 30 minutes before bedtime Cough <12 years: Safety and efficacy not established >12 years: 25-50 mg PO q4-6hr; not to exceed 300 mg/day Motion Sickness Administer 30 min before motion 12.5-25 mg PO q6-8hr or 150 mg/m² ; not to exceed 300 mg/day Renal Dose: Renal impairment: No dosage adjustment needed.

Masks ototoxicity produced by aminoglycosides. Increases gastric degradation of levodopa and decreases its absorption by reduction of gastric emptying. Antagonises therapeutic effects of cholinergic agents e.g. tacrine, donezepil and neuroleptics. Valerian, St. John's wort, Kava Kava and gotu kola may increase CNS depression. Potentially Fatal: Potentiates CNS depression with alcohol, barbiturates, analgesics, sedatives and neuroleptics. Additive antimuscarinic action with MAOIs, atropine and TCAs.

Hypersensitivity ; neonates, lactation.

Common - Dizziness - Drowsiness - Dryness in mouth Chest tightness, extrasystoles, hypotension, palpitations, tachycardia; ataxia, chills, confusion, dizziness, drowsiness, euphoria, excitement, fatigue, headache, insomnia, irritability, nervousness, neuritis, paraesthesia, paradoxical excitation, restlessness, sedation, seizure, vertigo; diaphoresis; menstrual disease; GI disturbances (e.g. anorexia, constipation, diarrhoea); difficulty in micturition, urinary frequency, urinary retention; agranulocytosis, haemolytic anaemia, thrombocytopenia; anaphylactic shock; tremor; blurred vision, diplopia; acute labyrinthitis, tinnitus; constriction of pharynx, nasal congestion, thickening of bronchial secretions, wheezing;

Category B: There are no adequate and well controlled studies in pregnant women using diphenhydramine hydrochloride. Therefore, diphenhydramine hydrochloride should be used in pregnancy only if clearly needed. Diphenhydramine hydrochloride has been reported to be excreted in breast milk and thus, use of diphenhydramine hydrochloride in lactating mother is not recommended.

Precaution: Epilepsy; elderly; performing tasks which require mental alertness; angle-closure glaucoma; pyroduodenal obstruction; urinary tract obstruction; hyperthyroidism; raised intraocular pressure; CV disease; acute asthma; pregnancy. Lactation: Drug enters breast milk; contraindicated

Symptoms: Impaired consciousness; psychosis, seizures, antimuscarinic symptoms (e.g. mydriasis, tachycardia, tachyarrhythmias), resp failure, rhabdomyolysis; acute delirium with visual and auditory hallucination (topical). Management: Supportive and symptomatic treatment. Convulsions and marked CNS stimulation may be treated with IV diazepam.

Store between 15-30° C. Protect from moisture.

Sedating Anti-histamine

Diphenhydramine blocks histamine H1-receptors on effector cells of the GI tract, blood vessels and respiratory tract. It also causes sedation and has some anticholinergic action.

Pregnancy category: B Lactation: Drug enters breast milk; contraindicated