Diaset 25 mg Tablet

Uses of Diaset: - Type 2 diabetes mellitus Type 2 DM Patient w/ diabetic ketoacidosis, inflammatory bowel disease, colonic ulceration, partial intestinal obstruction or predisposition to this condition, chronic intestinal diseases associated w/ marked disorders of digestion or absorption and co-existing conditions that may deteriorate as a result of increased intestinal gas formation.

Alpha-Glucosidase inhibitor

Miglitol reversibly inhibits membrane-bound intestinal α-glucosidase enzymes which hydrolyse oligosaccharides and disaccharides to glucose and other monosaccharides in the small intestinal brush border. It delays carbohydrate breakdown, glucose absorption and reduces postprandial hyperglycaemia.

How to use Miglitol: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Miglitol is to be taken with food. Administration: Should be taken with food. Take w/ 1st bite of each main meal. Adult Dose: Oral Type 2 diabetes mellitus Adult: Initially, 25 mg tid. Increase if necessary after 4-8 wk to 50 mg tid and continue for 3 mth. Max: 100 mg tid. Hepatic Impairment No admustment necessary Child Dose: Safety & efficacy not established Renal Dose: Renal Impairment Mild-moderate impairment: No dosage adjustment Severe impairment: Not recommended

Concomitant use w/ insulin increases the risk of hypoglycaemia. Intestinal adsorbents (e.g. charcoal) and carbohydrate-splitting digestive enzyme supplements (e.g. amylase, pancreatin) may reduce glycaemic effects. May significantly reduce the bioavailability of ranitidine and propranolol.

Patient w/ diabetic ketoacidosis, inflammatory bowel disease, colonic ulceration, partial intestinal obstruction or predisposition to this condition, chronic intestinal diseases associated w/ marked disorders of digestion or absorption and co-existing conditions that may deteriorate as a result of increased intestinal gas formation.

Common - Skin rash - Flatulence - Abdominal pain - Diarrhea >10% Flatulence (42%),Diarrhea (29%),Abdominal pain (12%) 1-10% Rash (4.3%) Frequency Not Defined Low serum iron

Category B: Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Precaution: Patient exposed to stress (e.g. fever, trauma, infection, surgery). Renal impairment. Pregnancy and lactation. Patient Counselling Adhere to diet and exercise regimen. Monitoring Parameters Periodic monitoring of blood glucose tests. Measure glycosylated Hb to monitor long term glycaemic control. Lactation: Enters slightly into breast milk; nor recommended

Store at 25° C.

Alpha-Glucosidase inhibitor

Miglitol reversibly inhibits membrane-bound intestinal ?-glucosidase enzymes which hydrolyse oligosaccharides and disaccharides to glucose and other monosaccharides in the small intestinal brush border. It delays carbohydrate breakdown, glucose absorption and reduces postprandial hyperglycaemia.

Category B: Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

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