Uses of Detomax IV: - Sedative ICU Sedation, Fiberoptic Intubation, Procedural Sedation 2nd or 3rd degree AV block (unless paced), uncontrolled hypotension, acute cerebrovascular disorders.

How to use Dexmedetomidine: Your doctor or nurse will give you this medicine. Kindly do not self administer. Administration: IV Preparation Dilute in NS IV Administration Infuse loading dose over 10 min Adult Dose: ICU Sedation Load: 1 mcg/kg IV over 10 minutes Maintenance 0.2-1.4 mcg/kg/hr IV Titrate less frequently than q30min to prevent hypotension Fiberoptic Intubation Load: 1 mcg/kg IV over 10 minutes Maintenance 0.7 mcg/kg/hr IV Procedural Sedation Load: 1 mcg/kg IV over 10 minutes Maintenance 0.6 mcg/kg/hr IV titrate to effect (usually 0.2-1 mcg/kg/hr) Titrate less frequently than q30min to prevent hypotension Hepatic Impairment Dose reduction may be required Child Dose: Safety and efficacy not established Renal Dose: Renal Impairment Dose reduction may be required

Enhanced pharmacologic effects of anaesth, sedatives, hypnotics, opiate agonists, other vasodilators or drugs that have negative chronotropic effects (e.g. cardiac glycosides).

2nd or 3rd degree AV block (unless paced), uncontrolled hypotension, acute cerebrovascular disorders.

Common - Decreased blood pressure - Dryness in mouth >10% Hypotension (28%) 1-10% AFib.Anemia,Bradycardia,Fever,Pleural effusion,Leukocytosis,Pulmonary edema

Precaution: Significant CV dysfunction, advanced heart block &/or severe ventricular dysfunction, hypovolemia, DM, chronic HTN. Renal & hepatic impairment. Do not inj by bolus or rapid IV. Do not administer for >24 hr. Pregnancy & lactation. Elderly. Childn <18 yr. Lactation: Excretion in milk unknown; use with caution

Centrally acting alpha2-adrenoceptor agonist that has sedative and anesthetic properties possibly by activating G-proteins in the brainstem, which results in the inhibition of norepinephrine release.

Pregnancy There are no adequate and well-controlled studies of use in pregnant women In an in vitro human placenta study, placental transfer of dexmedetomidine occurred Animal studies In pregnant rats, dexmedetomidine placental transfer observed when radiolabeled dexmedetomidine was administered SC Thus, fetal exposure should be expected in humans; use during pregnancy only if potential benefits justify potential fetal risk Lactation Unknown if excreted in human milk Radio-labeled dexmedetomidine administered SC to lactating female rats was excreted in milk Because many drugs are excreted in human milk, caution should be exercised when administered to breastfeeding women