Uses of Desocort: - Eczema - Atopic dermatitis Corticosteroid-responsive dermatoses Hypersensitivity

Other Topical corticosteroids

The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. This is achieved first by the drug binding to the glucocorticoid receptors which then translocates into the nucleus and binds to DNA causing various activations and repressions of genes. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.

How to use Desoximetasone: This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area. Adult Dose: Topical/Cutaneous Corticosteroid-responsive dermatoses Adult: As 0.05-0.25% cream/gel/lotion/oint: Apply a thin film onto affected area bid. Rub in gently. Child Dose: Topical/Cutaneous Corticosteroid-responsive dermatoses Child: As 0.05-0.25% cream/gel/lotion/oint: Apply a thin film onto affected area bid. Rub in gently.

May diminish the antineoplastic effect of aldesleukin. May potentiate the hyperglycaemic effect of ceritinib. May diminish the therapeutic effect of corticorelin and hyaluronidase. May enhance the adverse/toxic effects of deferasirox.

Hypersensitivity

Common - Application site reactions (burning, irritation, itching and redness) - Dryness Frequency Not Defined Skin atrophy Striae Acneform lesions Pruritus Irritation Miliaria Folliculitis Erythema Hypopigmentation Vesiculation Pigmentation changes HPA suppression (with higher potency used >2 wk)

Pregnancy Category C

Precaution: Childn. Pregnancy and lactation. Patient Counselling Avoid use of occlusive dressings. Topical spray is flammable, avoid exposure to heat and flame or smoking during or immediately after application. Monitoring Parameters Monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression through ACTH stimulation or urinary free cortisol test.

Topically applied corticostero systemic effects

Other Topical corticosteroids

Desoximetasone is a topical corticosteroid that induces phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid hence depresses the formation, release, and activity of endogenous chemical mediators such as kinins, histamine, liposomal enzymes, and prostaglandins.

Pregnancy Category: C Lactation: excretion in milk unknown; use with caution