Uses of Dapsone: - Leprosy Pneumonia, Acne, Leprosy, Dermatitis herpetiformis Hypersensitivity. Severe anaemia, porphyria.

Acne treatment preparations

Dapsone has both anti-infammatory and antimicrobial properties. A combination of these activities may account for its efcacy in acne. Anti-infammatory efects include inhibition of neutrophil myeloperoxidase and eosinophil peroxidase activity, suppression of hypochlorous acid production, scavenging of reactive oxygen species, suppression of neutrophil activity, and inhibition of chemoattractant-induced signal transduction. Antimicrobial activity, similar to that of sulfones and sulfonamides, is by inhibition of bacterial dihydropteroate synthase in the folic acid metabolic pathway. This mechanism is efective against microorganisms synthesizing their own folic acid. In vitro susceptibility testing has demonstrated some activity for Dapsone against Propionibacterium species, including Propionibacterium acnes (P. acnes).

How to use Dapsone: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Dapsone may be taken with or without food, but it is better to take it at a fixed time. Adult Dose: Dermatitis Herpetiformis 50 mg PO qDay, titrate to 300 mg qDay or higher to achieve desired effect Reduce dose to minimum effective dose within the range of 50-300 mg qDay as soon as possible Leprosy 100 mg PO qDay, in combination with other antileprosy drugs Tuberculoid or Lepromatous Disease 100 mg PO qDay with rifampin 600 mg PO qDay Child Dose: Child: PO 2 mg/kg, max 100 mg q24h 4 mg/kg, max 200 mg Once weekly

Decreased serum conc of dapsone when used with rifampicin. Increased plasma conc with probenecid, trimethoprim. Antagonize clofazimine.

Hypersensitivity. Severe anaemia, porphyria.

Common - Rash - Fever 1-10% Hemolysis,Methemoglobinemia <1% Reactional states (ie, abrupt changes in clinical activity occurring during any leprosy treatment; classified as reversal of erythema nodosum leprosum reactions),Insomnia,Headache,Exfoliative dermatitis,Photosensitivity,Nausea,Vomiting,Anemia,Leukopenia,Agranulocytosis,Hepatitis,Cholestatic jaundice,Peripheral neuropathy (usually in nonleprosy patients),Blurred vision,Tinnitus,SLE Potentially Fatal: Agranulocytosis, serious cutaneous hypersensitivity reactions, exfoliative dermatitis.

Pregnancy Category C. There are no adequate and well controlled studies in pregnant women. Dapsone should be used during pregnancy only if the potential beneft justifes the potential risk to the fetus.Although systemic absorption of Dapsone following topical application of Dapsone is minimal relative to oral Dapsone administration, it is known that Dapsone is excreted in human milk. Because of the potential for oral Dapsone to cause adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue Dapsone, taking into account the importance of the drug to the mother.

Precaution: G6PD deficiency, methaemoglobin or Hb M. Perform regular blood counts and monitor liver function regularly. Pregnancy and lactation. Lactation: Enters breast milk; not recommended (AAP Committee states "compatible with nursing")

Store in a cool & dry place. Keep out of reach of children. Do not freeze.

Acne treatment preparations

Dapsone inhibits folic acid synthesis by preventing normal bacterial utilization of PABA (PABA).

Pregnancy category: C Lactation: Enters breast milk; not recommended (AAP Committee states "compatible with nursing")