Uses of Cynomin-H: - Nutritional deficiencies Vitamin B12 deficiency, Cyanide poisoning Hypersensitivity to any component of this medication.

Antidote preparations, Drugs for Megaloblastic Anemia

Vitamin B12 with hydroxyl group complexed to cobalt which can be displaced by cyanide resulting in cyanocobaiamin that is renally excreted.

How to use Hydroxocobalamin: Your doctor or nurse will give you this medicine. Kindly do not self administer. Adult Dose: Adult Intramuscular 30 mcg daily for 5 to 10 days followed by 100 to 200 mcg monthly. Child Dose: Children Intramuscular 1 to 5 mg over a period of 2 or more weeks in doses of 100 mcg, then 30 to 50 mcg every 4 weeks for maintenance.

history of interaction with ARI Sodium Iodide (I123) 1-12 MBq (sodium iodide i-123) ARI Sodium Iodide (I123) 100-750 MBq (sodium iodide i-123) arsenic trioxide Chloracol (chloramphenicol) chloramphenicol Chloromycetin (chloramphenicol) Chloromycetin Sodium Succinate (chloramphenicol) Hicon (sodium iodide-i-131) Iodotope (sodium iodide-i-131) sodium iodide i-123 sodium iodide-i-131 Trisenox (arsenic trioxide)

Hypersensitivity to any component of this medication.

Common - Allergy - Flushing (sense of warmth in the face, ears, neck and trunk) - Anaphylactic reaction - Dark colored urine - Erythema (skin redness) Mild transient diarrhea, itching, transitory exanthema, feeling of swelling of entire body, and anaphylaxis. A few patients may experience pain after injection of hydroxocobalamin.

Pregnancy Category C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Precaution: The validity of diagnostic vitamin B12 or folic acid blood assays could be compromised by medications, and this should be considered before relying on such tests for therapy. Vitamin B12 is not a substitute for folic acid and since it might improve folic acid deficient megaloblastic anemia, indiscriminate use of vitamin B12 could mask the true diagnosis. Hypokalemia and thrombocytosis could occur upon conversion of severe megaloblastic to normal erythropoiesis with B12 therapy. Therefore, serum potassium levels and the platelet count should be monitored carefully during therapy. Vitamin B12 deficiency may suppress the signs of polycythemia vera. Treatment with vitamin B12 may unmask this condition.

Should be stored in cool and dry place

Antidote preparations, Drugs for Megaloblastic Anemia

Vitamin B12 with hydroxyl group complexed to cobalt which can be displaced by cyanide resulting in cyanocobalamin that is renally excreted.

Pregnancy Category C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks