Fungin 1%

Uses of Candid-V Tablet VT: - Fungal infections of vagina Vaginal itching, burning and discharge associated with recurrent vaginal yeast infections Vulvovaginal candidiasis (Vagonal thrush). Hypersensitivity.

Drugs for subcutaneous and mycoses, Topical Antifungal preparations

Clotrimazole is a broad spectrum antifungal. It also exhibits activity against Trichomonus, Staphylococci, Streptococci and Bacteroides. Clotrimazole kills fungi and yeasts by interfering with their cell membranes. It works by stopping the production of ergosterol, which is an essential component of fungal cell membranes resulting in increased membrane permeability and leakage of essential constituents of the fungal cells.

How to use Candid-V Tablet VT: Take this medicine in the dose and duration as advised by your doctor. Wash and dry your vaginal area. Dip the tablet in lukewarm water just to moisten it. Lie on your back and gently insert the tablet into the vagina as high as possible with or without the use of an applicator as mentioned in the label. It is best to use it just before bedtime. Adult Dose: Adult: Vaginal Vulvovaginal candidiasis: Clotrimazole VT 100 & 200- First infections: In general, a 3-day treatment is sufficient for Candida vaginitis. On 3 consecutive nights, Clotrimazole VT 100 or 1 Clotrimazole VT 200 are inserted as deeply as possible into the vagina. This is best achieved when lying on one’s back with the knees slightly bent. Re-infections: In general, a 6-day treatment is sufficient. This applies also to mixed infections with the above-mentioned causative organisms. On six consecutive nights, 1 Clotrimazole VT 100 is inserted as deeply as possible into the vagina. If necessary, 2 Clotrimazole VT 100 (1 in the morning and 1 in the evening) or 1 Clotrimazole VT 200 daily can be used for 6-12 days. Treatment should be timed so as to avoid the menstrual period and be finished before the onset of menstruation. To avoid re-infection, the partner should undergo local treatment with Clotrimazole Cream at the same time. Clotrimazole VT 500- Single dose, complete treatment with one vaginal tablet. The tablet should be inserted as deeply as possible in to the vagina. This is best achieved when lying on one’s back with the knees slightly bent. It is recommended that the treatment should be timed so as to avoid the menstrual period. For prevention of re-infection the partner should be treated locally with Clotrimazole Cream at the same time.

Antagonism with polyene antibiotics.

Hypersensitivity.

Common - Irritation - Vaginal burning sensation >10% Abnl LFTs 1-10% Mild burning, irritation, stinging to skin or vaginal area

Pregnancy Category B. Clotrimazole is recommended during pregnancy only after first consulting a doctor.Lactation: Because systemic absorption of clotrimazole following topical application is marginal, there should be no risk for the infant during lactation.

Precaution: Avoid contact with eyes upon topical application. Childn <3 yrs. Pregnancy, lactation. Lactation: Excretion in milk unknown; use with caution

Supportive measures should be taken incase of accidental oral ingestion.

Store at a cool and dry place. Protect from light. Do not freeze.

Clotrimazole is a broad-spectrum antifungal which binds to phospholipids in the cell membrane altering cell wall permeability causing a loss in essential intracellular elements.

Pregnancy Small amounts of imidazoles may be absorbed systemically following topical and vaginal administration Lactation Excretion in milk unknown; use with caution