Uses of Combocef 100: - Respiratory tract infection Pharyngitis, Acute otitis media, Community-acquired pneumonia, Sinusitis, UTI, Cystitis, Gonorrhea, Skin and skin structure infections, Tonsillitis, Respiratory tract infections, Acute Maxillary Sinusitis, Acute bacterial exacerbation of chronic bronchitis, Enteric fever Hypersensitivity.

How to use Cefpodoxime + Clavulanic Acid: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cefpodoxime + Clavulanic Acid may be taken with or without food, but it is better to take it at a fixed time. Administration: Should be taken with food. Take after meals. Adult Dose: Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis, Acute Maxillary Sinusitis 200 mg PO q12hr for 10 days Acute Community-Acquired Pneumonia 200 mg PO q12hr for 14 days Pharyngitis/Tonsillitis 100 mg PO q12hr for 5-10 days Skin/Skin Structure Infections 200-400 mg PO q12hr for 7-14 days Uncomplicated gonorrhoea 200 mg as a single dose Uncomplicated Urinary Tract Infections 100 mg PO q12hr for 7-14 days Complicated urinary tract infections 200 mg PO 12 hourly for 7 days Hepatic impairment Dosage adjustment not necessary Child Dose: Child : PO 10 mg/kg/day, max 400 mg/day q12h 6 months - 2 years : 40 mg every 12 hours 3 - 8 years : 80 mg every 12 hours over 9 years : 100 mg every 12 hours Renal Dose: Renal impairment: Patients on haemodialysis: Dose should be given after each dialysis session. CrCl (ml/min) Dosage Recommendation 10-39 Increase dosing intervals to 24 hrly. <10 Increase dosing intervals to 48 hrly.

Antacids or H2-blockers may decrease the absorption of cefpodoxime. Reduced renal excretion w/ probenecid.

Hypersensitivity.

Common - Nausea - Diarrhea - Stomach pain - Headache >10% Diarrhea in infants and toddlers (15.4%),Diaper rash (12.1%) 1-10% Diarrhea (7.4%),Nausea (3.8%),Vaginal infection (3.1%),Vomiting (1.1-2.1%),Abdominal pain (1.6%),Rash (1.4%),Headache (1.1%) Potentially Fatal: Pseudomembranous colitis; nephrotoxicity.

Xtabac 200 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Precaution: History of allergy to penicillin; severe renal impairment; pregnancy and lactation. Lactation: Drug excreted in breast milk in low concentrations; not recommended

Store in cool dry place & away from children.

Cefpodoxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Addition of clavulanate inhibits beta-lactamase-producing bacteria; Clavulanic acid has a high affinity for and binds to certain ?-lactamases that generally inactivate Cefpodoxime by hydrolyzing its ?-lactam ring. Combining clavulanate potassium with Cefpodoxime extends the antibacterial spectrum of Cefpodoxime to include many bacteria normally resistant to Cefpodoxime and other penicillins and cephalosporins.

Xtabac 200 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.