Caspa 50 mg
Voriconazole
Category: Tablet
Manufacturer: Aristopharma Ltd.
Price: 600.0 ৳
12's pack
piece
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Related Medicines
An azole antifungal drug is voriconazole. The following fungal infections are recommended for use in individuals 12 years of age and older.
Aspergillosis invasive
Disseminated candidiasis and candidemia (nonneutropenic) in the skin, abdomen, kidney, bladder wall, and wounds
Esophageal candidiasis
Severe infections brought on by Fusarium species include Fusarium solani
Scedosporium apiospermum
Those who are resistant to or intolerant of alternative treatments.
Other Antifungal preparations
The major mechanism of action of voriconazole is the suppression of 14 alpha-lanosterol demethylation, which is mediated by fungal cytochrome P450 and is a crucial step in the manufacture of fungal ergosterol. The buildup of 14 alpha-methyl sterols and subsequent loss of ergosterol from the fungal cell membrane may be what gives voriconazole its antifungal properties. It has been demonstrated that voriconazole is more selective for cytochrome P-450 enzymes found in fungi than for other cytochrome P-450 enzyme systems found in mammals.
Inhibitors and inducers of CYP3A4, CYP2C9, and CYP2C19: Voriconazole dosage should be changed, and side effects or ineffectiveness should be watched for.
Drugs that are CYP3A4, CYP2C9, and CYP2C19 substrates may have higher concentrations and activities when taken with voriconazole. Decrease these other drugs' dosages and keep an eye out for any negative effects
Raise the maintenance dose of oral and intravenous voriconazole when also taking phenytoin or efavirenz
Known sensitivity to the drug's active ingredient, voriconazole, or any other ingredient-
Risk of major adverse effects necessitates avoiding co-administration of sirolimus with terfenadine, astemizole, cisapride, pimozide, or quinidine.
Rifampin, carbamazepine, long-acting barbiturates, efavirenz, ritonavir, rifabutin, ergot alkaloids, and St. John's Wort should not be administered together due to the possibility of efficacy loss.
Abdominal pain, anemia, impaired vision, headaches, chest pain, nausea, and diarrhea are the most frequent adverse effects.
There aren't enough facts about voriconazole use during pregnancy. If the potential risk to the fetus is not clearly outweighed by the benefit to the mother, voriconazole should not be administered during pregnancy. There hasn't been any research done on voriconazole excretion into breast milk. Following the start of voriconazole treatment, breastfeeding must be discontinued.
The benefit-risk balance of long-term exposure (treatment or prophylaxis) of more than 180 days must be carefully weighed. Long-term voriconazole therapy has been linked to reports of squamous cell carcinoma of the skin (SCC).
There is no data found about overdose of Voriconazole.
Keep out of children's reach. Keep away from light in a dry area with a temperature below 25°C. Voriconazole powder for suspension should be kept between 2° and 8°C.
Other Antifungal preparations
A triazole antifungal drug called voriconazole is used to treat severe fungi infections. By preventing CYP450-dependent 14-alpha sterol demethylase from functioning, voriconazole binds and prevents the formation of ergosterol. Ergosterol levels in the membrane of fungal cells decrease as a result of the suppression of 14-alpha sterol demethylase.
There is no sufficient, carefully regulated research on pregnant women. Only if the possible benefit outweighs the potential risk to the fetus should it be taken during pregnancy.
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