Rheumatoid arthritis, Osteoarthritis, Chronic low back pain
Absorption of Diacerein is reduced if taken with aluminium and/or magnesium hydroxide antacid. Diacerein also increases risk of diarrhea if taken with laxatives, antibiotics. Avoid co-administration with fibers and phytic acids. Diacerein has shown hypersensitivity to anthraquinone derivatives.
Stimulation of Cartilage formation
Glucosamine is a natural substance produced in the human body and found in certain foods. Glucosamine stimulates the production of glycosaminoglycan & proteoglycan, two essential building blocks of cartilage. Glucosamine acts, as a supplement, as a joint lubricant and shock absorber necessary to maintain healthy cartilage and joint function. Diacerein is an anti-inflammatory analgesic and antipyretic drug, indicated specially for the treatment of arthritic conditions. It directly inhibits IL-1 synthesis and release in vitro and down modulates IL-1 induced activities and relieves Osteoarthritis.
Administration:
Should be taken with food. Take w/ or immediately after meals.
Adult Dose:
Oral
Osteoarthritis
Adults:
1 tablet twice daily
Child Dose:
Oral
Osteoarthritis
Children over 12 years and older:
1 tablet twice daily
Renal Dose:
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<30 25 mg daily.
Diacerein: Decreased absorption with aluminium and/or magnesium hydroxide antacids. Increased risk of diarrhoea with laxatives, antibiotics. Avoid co-admin with fibres and phytates.
Glucosamine: May reduce effect of antidiabetic agents, doxorubicin, etoposide, tenoposide. May enhance anticoagulant activity of warfarin.
Absorption of Diacerein is reduced if taken with aluminium and/or magnesium hydroxide antacid. Diacerein also increases risk of diarrhea if taken with laxatives, antibiotics. Avoid co-administration with fibers and phytic acids. Diacerein has shown hypersensitivity to anthraquinone derivatives.
Diacerein is contraindicated in pregnancy and lactation. Glucosamine should not be taken by pregnant women and nursing mothers due to lack of scientific data regarding its effect on fetus and infants.
Precaution:
Caution should be practiced when administering Diacerein + Glucosamine Sulphate in those patients who are allergic to Glucosamine and/or Diacerein or to shellfish (e.g., shrimp, crab); who have diabetes, asthma, alcohol dependence or liver disease. Before taking Diacerein + Glucosamine Sulphate complete blood count, liver function and urinalysis should be monitored regularly.
Diarrhea may occur.
Store in a cool & dry place, protect from light & moisture.
Diacerein is an anthraquinone derivative that has been used in osteoarthritis. It is thought to act via inhibition of interleukin-1. Glucosamine stimulates the production of proteoglycans and increases sulfate uptake by articular cartilage.
