Uses of Cabolin: - High levels of prolactin Hyperprolactinemia, prolactinomas, parkinson's disease, uterine fibroids, acromegaly, cushing's disease, pituitary adenomas, lactation suppression Hypersensitivity to ergot derivatives. Uncontrolled hypertension.

Antiparkinsonian Drug

Cabergoline is a long-acting dopamine receptor agonist with a high affinity for D2 receptors. It works by reducing the amount of prolactin that is released from pituitary gland. Results of in vitro studies demonstrate that Cabergoline exerts a direct inhibitory effect on the secretion of prolactin.

How to use Cabergoline: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cabergoline is to be taken with food. Administration: Should be taken with food. Adult Dose: Oral Inhibition of physiological lactation Adult: 1 mg as a single dose on the 1st day postpartum. Suppression of lactation Adult: 250 mcg every 12 hr for 2 days. Hyperprolactinaemia-associated disorders Adult: Initially, 500 mcg/wk then increased at mthly intervals by 500 mcg/wk according to response. Wkly dose may be admin on a single occasion or in 2 divided doses on separate days; doses >1 mg should be given as divided doses. Usual dose: 1 mg (up to 4.5 mg)/wk. As monotherapy in Parkinson's disease; Adjunct to levodopa treatment in Parkinson's disease Adult: Initially, 0.5 mg daily in monotherapy and 1 mg daily as adjunct, may increase in increments of 0.5-1 mg at 7- or 14-day intervals. Max: 3 mg daily. Elderly: Start with lower doses. Hepatic impairment: Dosage adjustments may be needed.

Increased risk of orthostatic hypotension when used with antihypertensives. May increase vasoconstriction effect of dopamine. May reduce vasodilation effect of nitroglycerin. Concurrent use with SSRIs or TCAs may increase the risk of serotonin syndrome. Potentially Fatal: Risk of serotonin syndrome with sibutramine.

Hypersensitivity to ergot derivatives. Uncontrolled hypertension.

Common - Blurred vision - Drowsiness - Hot flashes - Indigestion - Nausea - Constipation - Dizziness - Fatigue - Headache - Vertigo - Vomiting >10% Nausea (27%),Headache (26%),Dizziness (15%),Constipation (10%) 1-10% Asthenia (9%),Fatigue (7%),Abdominal pain (5%),Somnolence (5%),Postural hypotension (4%),Depression (3%),Dyspepsia (2%),Nervousness (2%),Abnormal vision (1%),Breast pain (1%),Dysmenorrhea (1%),Hot flashes (1%),Paresthesia (1%) Potentially Fatal: Risk of serotinin syndrome with sibutramine; avoid combination.

Pregnancy category B. It is not known whether this drug is excreted in human milk.

Precaution: CV disease, Raynaud's syndrome, renal or hepatic impairment, peptic ulcer, GI bleeding, history of psychosis, hypertension. May affect ability to drive or operate machinery. Pregnancy, lactation. Prolonged use and/or usage of high doses may lead to psychiatric disorders, pleural/retroperitoneal fibrosis or cardiac valvular fibrosis. Monitor serum prolactin level mthly until normalisation. Monitor hepatic function regularly in patients with hepatic impairment. Lactation: excretion in milk unknown; use with caution

Over dosage might be expected to produce nasal congestion, syncope, or hallucinations. Measures to support blood pressure should be taken if necessary.

Store below 25° C. Keep away from light, moisture & out of reach of children.

Antiparkinson drugs

Cabergoline is a long-acting dopamine D2-agonist. It inhibits prolactin secretion through hypothalamic inhibitory control exerted through the release of dopamine.

Pregnancy Category: B Lactation: excretion in milk unknown; not recommended