Uses of Breton: - Asthma - Chronic obstructive pulmonary disease (COPD) Chronic obstructive pulmonary disease Phaeochromocytoma.

Short-acting selective & β2-adrenoceptor stimulants

The primary pharmacological action of beta-adrenergic drugs is to stimulate adenyl cyclase, the enzyme which catalyzes the formation of cyclic-3',5' adenosine monophosphate (cyclic AMP) from adenosine triphosphate (ATP). The cyclic AMP thus formed mediates the cellular response that results in bronchodilation. Tulobuterol, due to its highly selective action on beta-2 adrenoceptors, relaxes the bronchial smooth muscle and has been shown to be clinically successful in the symptomatic treatment of reversible obstructive airways disease (ROAD) such as bronchial asthma, and also in bronchitis and emphysema.Some bronchodilators stimulate beta-1 (cardiac) receptors in addition to beta-2 receptors and may cause tachycardia, angina, and possibly arrhythmias in susceptible patients. Animal studies and in vitro experiments indicate that tulobuterol is more selective in its beta-2 agonist activity than other agents in this class and, therefore, should produce fewer cardiac side effects.

How to use Tulobuterol Hydrochloride: Use this medicine in dose and duration as advised by your doctor. Check the label before use. Make sure the skin is clean and dry. Remove the protective liner of the patch. Do not touch the sticky side. With sticky side down, place the patch evenly onto the skin. Adult Dose: Oral Bronchodilation Adult: Initially, 1-2 mg bid, increase to 2 mg tid if necessary. Child Dose: Oral Bronchodilation Child: 1-6 yr: 0.25-0.5 mg bid, 6-10 yr: 0.5-1 mg bid, 10-14 yr: 1-1.5 mg bid.

Increased risk of arrhythmia with digoxin. Hypokalaemia with concomitant admin of xanthines, corticosteroids and diuretics.

Phaeochromocytoma.

Common - Tremor - Headache - Restlessness - Insomnia (difficulty in sleeping) - Palpitations - Muscle cramp Fine tremor of skeletal muscle, palpitations, muscle cramps, tachycardia, nervous tension, headache, peripheral vasodilatation, hypersensitivity reactions.

Safety of this product for use during pregnancy has not been established. It is not known whether tulobuterol is excreted in human breast milk nor whether it has a harmful effect on the newborn. Therefore, as with any medication, the use of the drug in pregnancy, lactation, or women of childbearing potential requires that the expected therapeutic benefit of the drug be weighed against its possible hazards to the mother and child.

Precaution: Hyperthyroidism, myocardial insufficiency, arrhythmias, susceptibility to QT-interval prolongation, hypertension and DM.

Short-acting selective & β2-adrenoceptor stimulants

Tulobuterol is a direct-acting sympathomimetic with selective action on ?2-receptors. It is available orally, as a inhaler and as a transdermal patch. It is given as the hydrochloride by mouth and the base as transdermal formulation and inhalation.

Safety of this product for use during pregnancy has not been established. It is not known whether tulobuterol is excreted in human breast milk nor whether it has a harmful effect on the newborn. Therefore, as with any medication, the use of the drug in pregnancy, lactation, or women of childbearing potential requires that the expected therapeutic benefit of the drug be weighed against its possible hazards to the mother and child.