Artesunet 50mg
Artesunate
Category: Tablet
Manufacturer: Gaco Pharmaceuticals(G.A Company Ltd)
Price: 324.0 ৳
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Tablet
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Related Medicines
Uses of Artesunet:
- Malaria
Falciparum malaria especially in quinidine-resistant patients
Adult: PO: 4 mg/kg once daily x3 days (with mefloquine)
Anti-malarial drugs
Artesunate is a potent and rapidly-acting blood schizontocide derived from the leaves of the chinese herb, Armesia annua. The exact mode of action is not clear but clinical studies have confirmed the effectiveness of artesunate in P. vivax and falciparum malaria.
How to use Artesunate:
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Administration:
Antimalarial potentiating action seen with mefloquine, primaquine and tetracycline. Additive effect with chloroquine. Antagonistic effect with pyrimethamine and sulphonamides.
Adult Dose:
Hepatic or renal insufficiency. Pregnancy and lactation.
Lactation: unknown
Renal Dose:
Artesunate is a potent and rapidly-acting blood schizontocide derived from the leaves of the chinese herb, Armesia annua. The exact mode of action is not clear but clinical studies have confirmed the effectiveness of artesunate in P. vivax and falciparum malaria. Unclear, may inhibit DNA replication & transcription.
Hypersensitivity.
Artesunate is contraindicated for patients with known hypersensitivity to Artemisinin and its derivatives or its inactive ingredients.
Common
- Headache
- Dizziness
- Weakness
- Loss of appetite
Pregnancy category is not classified. FDA has yet not classified the drug into a specific pregnancy catagory.
Precaution:
Malaria, Schistosomiasis
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Anti-malarial drugs
Artesunate is metabolized to the active DHA. the endoperoxide bridge of DHA reacts with heme, generating free radicals which inhibit protein and nucleic acid synthesis of the Plasmodium parasites during all erythrocytic stages. Reactions with these free radicals can also lead to alkylation of parasitic proteins such as a calcium adenosine triphosphatase and EXP1, a glutathione S-transferase.
Generally well-tolerated, Cardiotoxicity (high doses), Neurotoxicity observed in animal studies, Drug induced fever, Skin rash
Samm Care